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Publikováno v:
Behavioural Brain Research. 305:65-75
Long-term intermittent hypoxia (IH) is a characteristic hallmark of obstructive sleep apnea (OSA) and causes most of the neurological aspects of OSA, such as spatial memory and learning deficits. These deficits are accompanied by an increase in oxida
Autor:
Chelsea A. Vadnie, Sun Choi, Doo Sup Choi, Alfredo Oliveros, Mario J. Hitschfeld, Jennifer R. Ayers-Ringler, Osama A. Abulseoud
Publikováno v:
Behavioural Brain Research. 305:8-17
Although neurotensin (NT) analogs are known to produce antipsychotic-like effects, the therapeutic possibility of a brain penetrant NTS1 agonist in treating psychiatric disorders has not been well studied. Here, we examined whether PD149163, a brain-
Publikováno v:
Behavioural Brain Research. 304:102-110
Development of disease modifying therapeutics for Parkinson's disease (PD), the second most common neurodegenerative disorder, relies on availability of animal models which recapitulate the disease hallmarks. Only few transgenic mouse models, which m
Autor:
Li Feng, Xinmin Liu, Yinghui Li, Shanguang Chen, Hong-wei Wu, Lina Qu, Cong Lu, Qi Chang, Guang-qing Song
Publikováno v:
Behavioural Brain Research. 302:60-68
Good sleep is necessary for optimal health, especially for mental health. Insomnia, sleep deprivation will make your ability to learn and memory impaired. Nevertheless, the underlying pathophysiological mechanism of sleep disorders-induced cognitive
Autor:
Samira S. Valvassori, Tatiani Bellettini-Santos, Amanda V. Steckert, Bruna Constantino Voss, Francielle Mina, João Quevedo, Sabrina da Silva, Michelle Lima Garcez, Josiane Budni, Robson Pacheco, Jesiel de Medeiros
Publikováno v:
Behavioural Brain Research. 302:35-43
d-Galactose (d-gal) is a reducing sugar that can be used to mimic the characteristics of aging in rodents; however, the effects of d-gal administration by oral route are not clear. Therefore, the aim of this study was to elucidate if the oral adminis
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Rationale Systemic administration of cannabidiol (CBD), the main non-psychotomimetic constituent of Cannabis sativa, induces antidepressant-like effects. The mechanism of action of CBD is thought to involve the activation of 5-HT1A receptors and the
Autor:
Rueben A. Gonzales, James M. Reno, Neha Thakore, Timothy J Schallert, Richard L. Bell, Christine L. Duvauchelle, W. Todd Maddox
Publikováno v:
Behavioural Brain Research. 302:228-236
Heightened emotional states increase impulsive behaviors such as excessive ethanol consumption in humans. Though positive and negative affective states in rodents can be monitored in real-time through ultrasonic vocalization (USV) emissions, few anim
Autor:
Piotr Wlaź, Katarzyna Socała
Publikováno v:
Behavioural Brain Research. 303:19-25
The transient receptor potential vanilloid 1 (TRPV1) receptor has recently gained attention as a new molecular target in the treatment of mental disorders such as depression and anxiety. α-Spinasterol is a plant steroid that acts as a TRPV1 antagoni
Autor:
Lee Tran, N. Bradley Keele
Publikováno v:
Behavioural Brain Research. 303:152-159
Hyperactivation of the amygdala is implicated in anxiety and mood disorders, but the precise underlying mechanisms are unclear. We previously reported that depletion of serotonin (5-hydroxytryptamine, 5-HT) in the basolateral nucleus of the amygdala
Autor:
Dexiang Liu, Lin Wu, Song Liu, Shishi Bo, Xuemei Bai, Hansen Liu, Tong Li, Zhen Wang, Yunkai Xie, Xueer Wang
Publikováno v:
Behavioural Brain Research. 302:191-199
Depression is one of the most common neuropsychiatric disorders and has been associated with oxidative stress and brain protein alterations. Resveratrol is a natural polyphenol enriched in Polygonum cuspidatum and has diverse biological activities in