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Role of the cAMP-PKA-CREB-BDNF pathway in abnormal behaviours of serotonin transporter knockout mice
Publikováno v:
Behavioural brain research. 419
Serotonin transporter gene-linked polymorphic region polymorphisms are associated with anxiety, neuroticism, affective disorders and vulnerability to stressful life events; however, the relevant physiological mechanisms are not well understood. Serot
Publikováno v:
Behavioural Brain Research. 363:83-93
Objective Accumulating evidence indicates an association between improved cognition and the early introduction of environmental enrichment (EE). The beneficial effect of EE has also been examined in the field of methamphetamine (METH) dependence. The
Autor:
Tadashi Nemoto, Akio Negishi, Tomoaki Sugiyama, Hayato Akimoto, Shinji Oshima, Daisuke Kobayashi
Publikováno v:
Behavioural Brain Research. 359:342-352
The ability to cope successfully with stress is known as ‘resilience’, and those with resilience are not prone to developing depression. One preclinical animal model for depression is the chronic mild stress (CMS) model. There are CMS-resilient (
Publikováno v:
Behav Brain Res
The dorsolateral striatum (DLS) is involved in addiction, reward, and alcohol related behaviors. The DLS primarily receives excitatory inputs which are gated by post-synaptic AMPA receptors. We antagonized AMPA receptors in the DLS to investigate how
Publikováno v:
Behavioural Brain Research. 353:203-209
Human immunodeficiency virus type 1 (HIV) has infected more than 40 million people worldwide and is associated with central nervous system (CNS) disruption in at least 30% of these persons. The use of highly active antiretroviral therapy (HAART) has
Autor:
Yan Wang, Jingwei Lv, Lina Qu, Xinmin Liu, Shanguang Chen, Fengzhong Wang, Yinghui Li, Bei Fan, Ning Jiang, Cong Lu
Publikováno v:
Behavioural Brain Research. 349:109-115
Sleep deprivation (SD) negatively caused cognitive deficit, which was associated with oxidative stress induced damage. Ginsenoside Rh2 had the ability to protect against damage caused by reactive oxygen species in vitro, showing antioxidant property.
Autor:
Yongping Zhang, Hao-Yin Wang, Zhilan Peng, Feng-Ming Liu, Yu-Yu Li, Zhang Cai, Bai-Ping Liu, Cai Song
Publikováno v:
Behavioural Brain Research. 347:436-445
Increased proinflammatory cytokines, such as interleukin (IL)-1β, may play an important role in the etiology of depression because they cause the hypothalamic–pituitary–adrenal axis to release glucocorticoids (GC) and induce dysfunction of serot
Autor:
Lu Yao, Ge-Juan Zhang, Yi-Na Sun, Li Zhang, Yong Wang, Jian Liu, Cheng-Xue Du, Hui-Sheng Wang
Publikováno v:
Behavioural Brain Research. 347:175-183
L-DOPA-induced dyskinesia (LID) is a frequent complication of chronic L-DOPA therapy in the clinical treatment of Parkinson's disease (PD). The pathogenesis of LID involves complex molecular mechanisms in the striatum. Metabolomics can shed light on
Autor:
Marina R. Picciotto, Tenna N. Mose, Benjamin W. Fait, Yann S. Mineur, David C. Thompson, Peter Jatlow, Sven E. Jordt
Publikováno v:
Behavioural Brain Research. 334:72-77
Menthol is a commonly used flavorant in tobacco and e-cigarettes, and could contribute to nicotine sensitivity. To understand how menthol could contribute to nicotine intake and addiction, it is important to determine whether specific mechanisms rela
Autor:
Ana Inés Ferreyra, Martina Sciangula, Aranza Wille-Bille, Michael E. Nizhnikov, Florencia Chiner, Ricardo Marcos Pautassi
Publikováno v:
Behavioural Brain Research. 332:269-279
Adolescents may be more sensitive to stress-induced alcohol drinking than adults, which would explain the higher prevalence of alcohol abuse and dependence in late adolescence than in adulthood. The present study analyzed the impact of restraint stre