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Autor:
Jianxin Yang, Yuxiao Tang, Chuyang Ye, Hui Shen, Mengyu Cai, Fengfeng Mo, Hongxia Li, Yinyin Zhang, Hongtao Lu, Xin Xu
Publikováno v:
Behavioural brain research. 418
Background Chronic stress is one of the most important causes of depression, accompanied by neuroinflammation and hippocampal injuries. Long-term elevation of glucocorticoid leads to activation of NF-κB and inhibition of GPR39/CREB/BDNF pathway, whi
Publikováno v:
Behavioural brain research. 417
In previous research, we found that chronic-intermittent ethanol administration (CIEA), a model of binge drinking, impaired emotional memory in mice, and this impairment was counteracted by the anti-inflammatory drug indomethacin. In the present stud
Publikováno v:
Behavioural brain research. 416
Hypobaric Hypoxia (HH) is known to cause oxidative stress in the brain that leads to spatial memory deficit and neurodegeneration . For decades therapeutic hypothermia is used to treat global and focal ischemia in preserving brain functions that prov
Autor:
Hossein Dinpanah, Mostafa Zare, Farimah Beheshti, Zahra Baradaran, Milad Hashemzehi, Arefeh Vakilian, Mahmoud Hosseini
Publikováno v:
Behavioural brain research. 411
Objective Adolescence is a crucial time for brain maturation. We investigated the protective effects of metformin (Met) on behavioral changes, oxidative stress, tumor necrosis factor alpha (TNF-α) and nitrite in adulthood induced by ethanol (Eth) co
Autor:
Angela Maria Casaril, Darling de Andrade Lourenço, Micaela Domingues, Beatriz Vieira, Lucielli Savegnago, Suely Ribeiro Bampi, Paloma Taborda Birmann, César Augusto Brüning, Tiago Collares, Mariana Souza Sonego, Luiz H. Dapper, Fabiana Kömmling Seixas, Eder J. Lenardão
Publikováno v:
Behavioural Brain Research. 366:96-107
In the last decades, selenium-containing compounds have received increasing attention due to their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl) selanyl]-2-phenylimidazo[1
Autor:
Cristian Gerónimo-Olvera, Lucía Quevedo-Corona, Mireya Alcaraz-Zubeldia, Francisca Pérez-Severiano, Juan Carlos Martínez-Lazcano, Alicia Sánchez-Mendoza, M. Alejandra Hernández-Melesio, Camilo Ríos, María E. Jiménez-Capdeville, Martha E. Santoyo-Pérez
Publikováno v:
Behavioural Brain Research. 366:108-117
Nitric oxide (NO) plays a leading role in learning and memory processes. Previously, we showed its ability to modify the deleterious effect of immunotoxin 192 IgG-saporin (192-IgG-SAP) in the cholinergic system. The aim of this study was to analyze t
Autor:
Yanli Zhang, Fengrui Cao, Qing Liu, Shansong Yi, Jianmei Ma, Xiaohan Yang, Xinsheng Li, Fenghua Xu, Kai Fan, Gang Liu, Xinnan Zhao, Guoyang Xu
Publikováno v:
Behavioural Brain Research. 364:494-502
The immuno-inflammatory activation triggered by various stresses play an important role in pathophysiology of depression. The immune responses display differential pathological characters in different stresses. However, comparative data and analysis
Autor:
Xiao-Yu Yin, Xiu Yang, Can Gao, Le Liu, Han Gao, Jing-Ru Hao, Qi-Kai Tang, De-Qin Geng, Wei Wang, Luo-Yue Yin
Publikováno v:
Behavioural Brain Research. 364:75-84
Chronic stress is an important factor for depression. Most individuals recover from stress, while some develop into depression. The pathogenesis of resilience or susceptibility remains unclear. Stress activates the hypothalamic-pituitary-adrenal (HPA
Publikováno v:
Behavioural Brain Research. 363:83-93
Objective Accumulating evidence indicates an association between improved cognition and the early introduction of environmental enrichment (EE). The beneficial effect of EE has also been examined in the field of methamphetamine (METH) dependence. The
Publikováno v:
Behavioural Brain Research. 362:288-298
Glucocorticoids are vital stress response hormones and facilitate stress coping. However, sustained glucocorticoid exposure is associated with negative effects on brain. The precise role of glucocorticoids in depression and anxiety remains unclear. I