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Autor:
Jianxin Yang, Yuxiao Tang, Chuyang Ye, Hui Shen, Mengyu Cai, Fengfeng Mo, Hongxia Li, Yinyin Zhang, Hongtao Lu, Xin Xu
Publikováno v:
Behavioural brain research. 418
Background Chronic stress is one of the most important causes of depression, accompanied by neuroinflammation and hippocampal injuries. Long-term elevation of glucocorticoid leads to activation of NF-κB and inhibition of GPR39/CREB/BDNF pathway, whi
Autor:
Angela Maria Casaril, Darling de Andrade Lourenço, Micaela Domingues, Beatriz Vieira, Lucielli Savegnago, Suely Ribeiro Bampi, Paloma Taborda Birmann, César Augusto Brüning, Tiago Collares, Mariana Souza Sonego, Luiz H. Dapper, Fabiana Kömmling Seixas, Eder J. Lenardão
Publikováno v:
Behavioural Brain Research. 366:96-107
In the last decades, selenium-containing compounds have received increasing attention due to their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl) selanyl]-2-phenylimidazo[1
Autor:
Xiao-Yu Yin, Xiu Yang, Can Gao, Le Liu, Han Gao, Jing-Ru Hao, Qi-Kai Tang, De-Qin Geng, Wei Wang, Luo-Yue Yin
Publikováno v:
Behavioural Brain Research. 364:75-84
Chronic stress is an important factor for depression. Most individuals recover from stress, while some develop into depression. The pathogenesis of resilience or susceptibility remains unclear. Stress activates the hypothalamic-pituitary-adrenal (HPA
Publikováno v:
Behavioural Brain Research. 361:159-166
One-trial contextual fear conditioning in laboratory mice results in a fear memory which is relatively specific to the original conditioning context shortly after conditioning but becomes more unspecific after an incubation time of one month. This pr
Publikováno v:
Behavioural Brain Research. 353:203-209
Human immunodeficiency virus type 1 (HIV) has infected more than 40 million people worldwide and is associated with central nervous system (CNS) disruption in at least 30% of these persons. The use of highly active antiretroviral therapy (HAART) has
Publikováno v:
Behavioural brain research. 405
Methamphetamine (MA) is a highly addictive psychomotor stimulant drug. Research has shown that the acute effects of MA can be modulated by age, although previous findings from our lab do not find age differences in the effects of MA. Relatively littl
Autor:
Natássia Lopes Cunha, Tatiana de Queiroz Oliveira, Michelle Verde Ramos Soares, Paloma Marinho Jucá, Charliene Freire Xavier Vieira, Silvânia Maria Mendes Vasconcelos, Adriano José Maia Chaves Filho, Gabriela Mariângela Farias de Oliveira, Danielle Silveira Macêdo, Carlos Venício Jatai Gadelha Filho, Glautemberg de Almeida Viana
Publikováno v:
Behavioural Brain Research. 419:113667
Mirtazapine (MIRT) is a multi-target antidepressant used in treatment of severe depression with promising efficacy, but also with important side effects, mainly sedation and weight gain. Thus, the present study aimed to test the effects of the neurop
Autor:
Angela Maria Casaril, Paloma Taborda Birmann, Micaela Domingues, Lucielli Savegnago, Thiago Ângelo Smaniotto, Daniela Hartwig, Raquel G. Jacob
Publikováno v:
Behavioural brain research. 396
The contribution of oxidative stress has been described in numerous studies as one of the main pathways involved in the pathophysiology of anxiety and its comorbidities, such as chronic pain. Therefore, in this study, we investigated the anxiolytic-l
Publikováno v:
Behavioural brain research. 395
Probiotic antidepressant effects demonstrated previously in clinical studies and animal models act via unknown mechanisms. Here we used a corticosterone injection-induced Sprague-Dawley rat chronic stress exposure model to investigate antidepressant-
Autor:
Guirong Zeng, Shanshan Li, Xinmin Liu, Hong Huang, Haixia Wang, Ning Jiang, Lv Jing-Wei, Qiong Wang
Publikováno v:
Behavioural brain research. 393
20 (S)-protopanaxadiol (PPD) possesses a variety of biological activities, including antioxidant, antifatigue and anti-inflammatory properties. This study was aimed to investigate the antidepressant-like effects of PPD and potential mechanisms in rat