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Publikováno v:
Behav Brain Res
The dorsolateral striatum (DLS) is involved in addiction, reward, and alcohol related behaviors. The DLS primarily receives excitatory inputs which are gated by post-synaptic AMPA receptors. We antagonized AMPA receptors in the DLS to investigate how
Autor:
Marina R. Picciotto, Tenna N. Mose, Benjamin W. Fait, Yann S. Mineur, David C. Thompson, Peter Jatlow, Sven E. Jordt
Publikováno v:
Behavioural Brain Research. 334:72-77
Menthol is a commonly used flavorant in tobacco and e-cigarettes, and could contribute to nicotine sensitivity. To understand how menthol could contribute to nicotine intake and addiction, it is important to determine whether specific mechanisms rela
Autor:
Daniel J. Peterson, W. Drew Gill, Elizabeth D. Cummins, James R. Pauly, Russell W. Brown, John M. Dose, Katherine C. Burgess, Donald B. Hoover
Publikováno v:
Behavioural Brain Research. 325:17-24
Neonatal quinpirole (NQ) treatment to rats increases dopamine D2 receptor sensitivity persistent throughout the animal's lifetime. In Experiment 1, we analyzed the role of α7 and α4β2 nicotinic receptors (nAChRs) in nicotine behavioral sensitizati
Publikováno v:
Behavioural Brain Research. 314:96-105
Prenatal alcohol exposure can produce permanent alterations in brain structure and profound behavioral deficits. Mouse models can help discover mechanisms and identify potentially useful interventions. This study examined long-term influences of eith
Autor:
Brandi C. Fink, Daniel D. Savage, Daniel Barto, Suzy Davies, Nathan S. Pentkowski, Clark W. Bird, Christy M. Magcalas, Derek A. Hamilton, Carlos I. Rodriguez, James P. Rice
Publikováno v:
Behavioural Brain Research. 313:233-243
Persistent deficits in social behavior, motor behavior, and behavioral flexibility are among the major negative consequences associated with exposure to ethanol during prenatal development. Prior work from our laboratory has linked moderate prenatal
Autor:
Lindsey G. Andres-Beck, Sun Choi, Alfredo Oliveros, Doo Sup Choi, David J. Hinton, Kelle E. Nett, Marin Veldic
Publikováno v:
Behav Brain Res
Adolescent’s consumption of caffeine and caffeinated beverage is increasing, yet little is known about the consequences of chronic caffeine exposure during the critical development period of adolescence. In the present study, we investigated the ef
Publikováno v:
Behav Brain Res
Studies with human subjects indicate that ethanol exposure during fetal development causes long-lasting alterations in motor coordination that are, in part, a consequence of cerebellar damage. Studies with rats exposed to ethanol during the neonatal
Publikováno v:
Behavioural Brain Research. 300:77-84
The impact of ambient light on mood and anxiety is best exemplified in seasonal affective disorder, in which patients experience depression and anxiety in winter when there is less light in the environment. However, the brain mechanisms underlying li
Publikováno v:
Behavioural brain research
Oxytocin has a modulatory role in natural and drug reward processes. While the role of oxytocin in pair bonding and reproduction has been extensively studied, sex differences in conditioned and unconditioned behavioral responses to oxytocin treatment
Publikováno v:
Behavioural Brain Research. 268:229-238
Attention Deficit Hyperactivity Disorder (ADHD) is associated with dysfunctional prefrontal and striatal circuitry and dysregulated dopamine neurotransmission. Spontaneously Hypertensive Rats (SHR), a heuristically useful animal model of ADHD, were e