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Autor:
Angela Maria Casaril, Darling de Andrade Lourenço, Micaela Domingues, Beatriz Vieira, Lucielli Savegnago, Suely Ribeiro Bampi, Paloma Taborda Birmann, César Augusto Brüning, Tiago Collares, Mariana Souza Sonego, Luiz H. Dapper, Fabiana Kömmling Seixas, Eder J. Lenardão
Publikováno v:
Behavioural Brain Research. 366:96-107
In the last decades, selenium-containing compounds have received increasing attention due to their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl) selanyl]-2-phenylimidazo[1
Autor:
Cristian Gerónimo-Olvera, Lucía Quevedo-Corona, Mireya Alcaraz-Zubeldia, Francisca Pérez-Severiano, Juan Carlos Martínez-Lazcano, Alicia Sánchez-Mendoza, M. Alejandra Hernández-Melesio, Camilo Ríos, María E. Jiménez-Capdeville, Martha E. Santoyo-Pérez
Publikováno v:
Behavioural Brain Research. 366:108-117
Nitric oxide (NO) plays a leading role in learning and memory processes. Previously, we showed its ability to modify the deleterious effect of immunotoxin 192 IgG-saporin (192-IgG-SAP) in the cholinergic system. The aim of this study was to analyze t
Publikováno v:
Behavioural Brain Research. 367:128-142
Estrogens receptors (ER) are involved in several sociosexual behaviors and fear responses. In particular, the ERα is important for sexual behaviors, whereas ERβ modulates anxiolytic responses. Using shRNA directed either against the ERα or the ER
Autor:
Yanli Zhang, Fengrui Cao, Qing Liu, Shansong Yi, Jianmei Ma, Xiaohan Yang, Xinsheng Li, Fenghua Xu, Kai Fan, Gang Liu, Xinnan Zhao, Guoyang Xu
Publikováno v:
Behavioural Brain Research. 364:494-502
The immuno-inflammatory activation triggered by various stresses play an important role in pathophysiology of depression. The immune responses display differential pathological characters in different stresses. However, comparative data and analysis
Autor:
Xiao-Yu Yin, Xiu Yang, Can Gao, Le Liu, Han Gao, Jing-Ru Hao, Qi-Kai Tang, De-Qin Geng, Wei Wang, Luo-Yue Yin
Publikováno v:
Behavioural Brain Research. 364:75-84
Chronic stress is an important factor for depression. Most individuals recover from stress, while some develop into depression. The pathogenesis of resilience or susceptibility remains unclear. Stress activates the hypothalamic-pituitary-adrenal (HPA
Publikováno v:
Behavioural Brain Research. 363:83-93
Objective Accumulating evidence indicates an association between improved cognition and the early introduction of environmental enrichment (EE). The beneficial effect of EE has also been examined in the field of methamphetamine (METH) dependence. The
Publikováno v:
Behavioural Brain Research. 362:288-298
Glucocorticoids are vital stress response hormones and facilitate stress coping. However, sustained glucocorticoid exposure is associated with negative effects on brain. The precise role of glucocorticoids in depression and anxiety remains unclear. I
Publikováno v:
Behavioural Brain Research. 361:159-166
One-trial contextual fear conditioning in laboratory mice results in a fear memory which is relatively specific to the original conditioning context shortly after conditioning but becomes more unspecific after an incubation time of one month. This pr
Publikováno v:
Behavioural Brain Research. 360:312-322
Early life immune challenges are risk factors for neurodevelopmental disorders. In adolescence, they elicit behavioral symptoms that resemble clinical disorders. Stressors during this time may alter signaling from the gut microbiome, which increases
Autor:
Tadashi Nemoto, Akio Negishi, Tomoaki Sugiyama, Hayato Akimoto, Shinji Oshima, Daisuke Kobayashi
Publikováno v:
Behavioural Brain Research. 359:342-352
The ability to cope successfully with stress is known as ‘resilience’, and those with resilience are not prone to developing depression. One preclinical animal model for depression is the chronic mild stress (CMS) model. There are CMS-resilient (