Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Runliu Wu, Daniel J. Klionsky, Daolin Tang, Xin Chen, Jingbo Li, Xinxin Song, Herbert J. Zeh, Yinghua Xu, Xiaoyan Wang, Rui Kang, Jiao Liu
Publikováno v:
Autophagy
Macroautophagy (hereafter referred to as “autophagy”) is a lysosome-mediated degradation process that plays a complex role in cellular stress, either promoting survival or triggering death. Early studies suggest that ferroptosis, an iron-dependen
Publikováno v:
Autophagy
Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter “autophagy”) is one of the lysosome-dependent degradation systems that
Autor:
Guido Kroemer, Yangchun Xie, Leng Han, Herbert J. Zeh, Enyong Dai, Jiao Liu, Rui Kang, Daniel J. Klionsky, Jing Wang, Daolin Tang
Publikováno v:
Autophagy
KRAS is the most frequently mutated oncogene in human neoplasia. Despite a large investment to understand the effects of KRAS mutation in cancer cells, the direct effects of the oncogenetic KRAS activation on immune cells remain elusive. Here, we rep
Publikováno v:
Autophagy. 14:2173-2175
Ferroptosis is a form of regulated cell death triggered by lipid peroxidation after inhibition of the cystine/glutamate antiporter system X(c)(−). However, key regulators of system X(c)(−) activity in ferroptosis remain undefined. Here, we show t
Autor:
Wen Hou, Herbert J. Zeh, Daolin Tang, Xinxin Song, Rui Kang, Yangchun Xie, Michael T. Lotze, Xiaofang Sun
Publikováno v:
Autophagy. 12:1425-1428
Macroautophagy/autophagy is an evolutionarily conserved degradation pathway that maintains homeostasis. Ferroptosis, a novel form of regulated cell death, is characterized by a production of reactive oxygen species from accumulated iron and lipid per
Publikováno v:
Dev Cell
Pancreatic cancer is an aggressive malignancy with changes in the tumor microenvironment. Here, we demonstrate that PINK1 and PARK2 suppressed pancreatic tumorigenesis through control of mitochondrial iron-dependent immunometabolism. Using mouse mode
Publikováno v:
Autophagy. 8:989-991
Pancreatic ductal adenocarcinoma (PDA), the fourth leading cause of cancer death in the United States, is a complex disease that arises in the setting of genetic alterations (KRAS, BRCA1, SMAD4, CDKN2A/p16 (INK4a) and TP53), epigenetic perturbations
Publikováno v:
Autophagy. 8:846-848
Tumorigenesis and the efficacy of cancer therapeutics are both defined by the balance between autophagy and apoptosis. High-mobility group box 1 (HMGB1) is a DNA chaperone and extracellular damage-associated molecular pattern molecule (DAMP) with pro
Publikováno v:
Autophagy. 7:904-906
High mobility group box 1 (HMGB1) is a DNA-binding nuclear protein, actively released following cytokine stimulation as well as passively during cell injury and death. Autophagy is a tightly regulated cellular stress pathway involving the lysosomal d
Publikováno v:
Autophagy. 7:442-444
The receptor for advanced glycation end products (RAGE) plays a crucial role in several disease processes including diabetes, inflammation, and cancer. Compared with apoptosis ("programmed cell death"), autophagy is a genetically programmed, evolutio