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Autor:
Yulong He, Yanbo Zhang, Hongyan Wang, Li Ma, Luqing Zhang, Yongning He, Weiyun Li, Na Li, Yichun Wu, Fei Zhou, Linlin Qi, Yao Lu, Bin Wei, Hongxiu Yu, Qi Zhao
Publikováno v:
Autophagy
Macrophages rapidly undergo glycolytic reprogramming in response to macroautophagy/autophagy, inflammasome activation and pyroptosis for the clearance of bacteria. Identification the key molecules involved in these three events will provide critical
Autor:
Shikun Yang, Aimei Li, Qin Liao, Hao Zhang, Li Zheng, Hailong Han, Jianwen Wang, Bin Yi, Zhaoxin Hu
Publikováno v:
Autophagy. 18:877-890
Diabetic nephropathy (DN) has become a major cause of end-stage renal disease, and autophagy disorder is implicated in the pathogenesis of DN. Our previous studies found that vitamin D (VD) and VDR (vitamin D receptor) played a renoprotective role by
Autor:
Yu-Hong Chen, Jia Mai, Jun-Hao Huang, Rong Deng, Xiao Feng Zhu, Zhi-Peng Ye, Zhi-Ling Li, Jun Tang, Xiao-Dan Peng, Jun-Dong Li, Xuan Li, Bing-Xin Hu, Hai-Liang Zhang, Gong-Kan Feng, Ruizhao Cai, Yun Huang, Yan Wang
Publikováno v:
Autophagy
The function of mitophagy in cancer is controversial. ULK1 is critical for induction of macroautophagy/autophagy and has a more specific role in mitophagy in response to hypoxia. Here, we show that ULK1 deficiency induces an invasive phenotype of bre
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
In the preceding months, the novel SARS-CoV-2 pandemic has devastated global communities. The need for safe and effective prophylactic and therapeutic treatments to combat COVID-19 – the human disease resulting from SARS-CoV-2 infection – is clea
Autor:
Mirella Meregalli, Josée N. Lavoie, Viola Oorschot, Keith E. Schulze, Emily A. McKaige, Emily C. Baxter, Emmanuelle Lacène, Keyne Monro, Margit Fuchs, Rita J. Serrano, Avnika A. Ruparelia, Clara Yun Qi Lee, Caitlin Williams, Robert J. Bryson-Richardson, Georg Ramm, Yvan Torrente, Tanya Stojkovic
Publikováno v:
Autophagy
Dominant de novo mutations in the co-chaperone BAG3 cause a severe form of myofibrillar myopathy, exhibiting progressive muscle weakness, muscle structural failure, and protein aggregation. To elucidate the mechanism of disease in, and identify thera
Autor:
Sohha Ariannejad, Marisa McGrath, Zhiqiang Hu, Matthew B. Frieman, Katelyn Miller, Stuart Weston, William T. Jackson
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, is the most recent example of an emergent coronavirus that poses a significant threat to human health. Virus-host interactions play a major role in the viral life cycle and disease pathogenesis,
Autor:
Amy H. Ponsford, Laura E. Swan, Emanuele Cocucci, Florian Fröhlich, Andrea Raimondi, Thomas A. Ryan, Massimiliano Stagi, Susanne A. Wycislo
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Disorders of lysosomal physiology have increasingly been found to underlie the pathology of a rapidly growing cast of neurodevelopmental disorders and sporadic diseases of aging. One cardinal aspect of lysosomal (dys)function is lysosomal acidificati
Autor:
Han Hu, Shuoshuo Li, Jifeng Guo, Xiangxi Kong, Cungen Ma, Mingtao Li, Xiaoheng Li, Jiezhong Yu, Jinbo Cheng, Jianke Li, Nannan Yang, Zengqiang Yuan, Lixia Qin, Yajin Liao, Yuan Dong, Beisha Tang
Publikováno v:
Autophagy
Microglial activation-induced neuroinflammation is closely associated with the development of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological processes, but the role of autophagy in microglial activation during PD developme
Autor:
Nancy Braverman, Elie Khoury, Erminia Di Pietro, Sathyen A. Prabhu, Alicia M. Bolt, François-Michel Boisvert, Fan Huang, Sonia V. del Rincón, John K. Heath, Wilson H. Miller, Koren K. Mann, Raúl Ernesto Flores González, Alexandre Orthwein, Christophe Goncalves, Zi Yi Xu, Michael S. Dahabieh, Joelle Rémy-Sarrazin
Publikováno v:
Autophagy
Promoting the macroautophagy/autophagy-mediated degradation of specific proteins and organelles can potentially be utilized to induce apoptosis in cancer cells or sensitize tumor cells to therapy. To examine this concept, we enriched for autophagosom
Autor:
Zhao Huang, Wei Gao, Li Zhou, Yuan Liu, Hai-Ning Chen, Yunlong Lei, Yuelong Wang, Kui Wang, Ke Xie, Jiang Lan, Canhua Huang, Edouard C. Nice, Ping Jin, Yuquan Wei, Lu Zhang, Tao Zhang, Liangxue Zhou, Yihai Cao, Bowen Li, Jingwen Jiang, Yong Peng
Publikováno v:
Autophagy. 16:106-122
GBM (glioblastoma multiforme) is the most common and aggressive brain tumor with no curative options available. Therefore, it is imperative to develop novel potent therapeutic drugs for GBM treatment. Here, we show that regorafenib, an oral multi-kin