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Publikováno v:
Autophagy. 17:1278-1280
Alzheimer disease (AD) is a neurodegenerative disorder for which no approved medication exists. AD is characterized by worsening cognitive and non-cognitive symptoms, and research in the AD field strives to identify very precocious brain alterations
Autor:
Han Hu, Shuoshuo Li, Jifeng Guo, Xiangxi Kong, Cungen Ma, Mingtao Li, Xiaoheng Li, Jiezhong Yu, Jinbo Cheng, Jianke Li, Nannan Yang, Zengqiang Yuan, Lixia Qin, Yajin Liao, Yuan Dong, Beisha Tang
Publikováno v:
Autophagy
Microglial activation-induced neuroinflammation is closely associated with the development of Parkinson disease (PD). Macroautophagy/autophagy regulates many biological processes, but the role of autophagy in microglial activation during PD developme
Autor:
Guillaume Robert, Patrick Auberger
Publikováno v:
Autophagy
Chaperone-mediated autophagy (CMA) is a selective form of autophagy that allows the elimination and recycling of cytosolic proteins endowed with a KFERQ-like motif into the lysosome. During this process, the proteins to be degraded are recognized by
Autor:
Alberto Villanueva, Maria Santacana, Jordi Ponce, Sonia Gatius, Maria Dolores Martí, Nuria Eritja, Xavier Dolcet, Andree Yeramian, August Vidal, Laura Bergadà, Xavier Matias-Guiu, Jeff Boyd, Jaume Reventós, Ruth Rodriguez-Barrueco, Joan Muela Ribera, Mario Encinas, Bo-Juen Chen, David Llobet-Navas
Publikováno v:
Repositorio Abierto de la UdL
Universitad de Lleida
Autophagy
Recercat. Dipósit de la Recerca de Catalunya
instname
Universitad de Lleida
Autophagy
Recercat. Dipósit de la Recerca de Catalunya
instname
Targeted therapies in endometrial cancer (EC) using kinase inhibitors rarely result in complete tumor remission and are frequently challenged by the appearance of refractory cell clones, eventually resulting in disease relapse. Dissecting adaptive me
TFEB and trehalose drive the macrophage autophagy-lysosome system to protect against atherosclerosis
Publikováno v:
Autophagy. 14:724-726
In the atherosclerotic plaque, macrophages are the key catabolic workhorse responsible for clearing lipid and dead cell debris. To survive the highly proinflammatory and lipotoxic plaque environment, macrophages must adopt strategies for maintaining
Autor:
Seok-Hyung Kim, Jin-Woo Bae, Min-Soo Kim, Jinyoung Kim, June Chul Lee, Myung-Shik Lee, Kyu Yeon Hur, Hae Youn Lee, Wenying Quan
Publikováno v:
Autophagy. 12:1390-1403
Autophagy, which is critical for the proper turnover of organelles such as endoplasmic reticulum and mitochondria, affects diverse aspects of metabolism, and its dysregulation has been incriminated in various metabolic disorders. However, the role of
Autor:
Jingyu Wan, Huile Gao, Xinle Gao, Dandan Xie, Kairong Shi, Guanlian Hu, Jiandong Duan, Jiajing Tang, Yang Wang, Li Zhang, Sheng Yin, Ming Qin, Zhirong Zhang, Qin He, Neng Wang
Publikováno v:
Autophagy. 12:949-962
Hydroxychloroquine (HCQ) inhibits autophagy and therefore can sensitize some cancer cells to chemotherapy, but the high doses required limit its clinical use. Here we show that loading HCQ into liposomes (HCQ/Lip) decorated with a pH-sensitive TH-RGD
Autor:
Gillian Carleton, Julian J. Lum
Publikováno v:
Autophagy. 15:1648-1649
Macroautophagy/autophagy is a critical regulator of adaptive T cell immunity and homeostasis. However, the role of T cell autophagy in regulating antitumor immune responses is less clear. In a recent study, we showed that deletion of the essential au
Autor:
Jennifer S. Carew, Steffan T. Nawrocki
Publikováno v:
Autophagy. 13:765-766
Although macroautophagy/autophagy is a key contributor to malignant pathogenesis and therapeutic resistance, there are few FDA-approved agents that significantly affect this pathway. We used medicinal chemistry strategies to develop ROC-325, an orall