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Autor:
Hideki Suganami, Koutaro Yokote, Hidenori Arai, Eiichi Araki, Shun Ishibashi, Shizuya Yamashita
Publikováno v:
Atherosclerosis. 261
Substantial residual cardiovascular risks remain despite intensive statin treatment. Residual risks with high triglyceride and low high-density lipoprotein cholesterol are not the primary targets of statins. K-877 (pemafibrate) demonstrated robust ef
Autor:
Ji Hyun Kim, Jung-Ah Shin, Sang-Ah Chang, Soon-Jib You, Jung Min Lee, Sung-Soo Lee, Ma-Rie Lee, Kun-Ho Yoon
Publikováno v:
Atherosclerosis. 227:355-359
Objective Pravastatin has been reported to elevate circulating adiponectin levels in patients with various insulin resistant state, hypertension, coronary artery disease, and hypercholesterolemia. This study aimed to evaluate whether pravastatin incr
Autor:
Alexandros D. Tselepis, Moses Elisaf, Elisavet Moutzouri, Constantinos C. Tellis, Evangelos Liberopoulos, Kleopatra Rousouli, H. J. Milionis
Publikováno v:
Atherosclerosis. 225:381-387
Toll-like receptors (TLRs) are key players in the innate immune system. Recently, a pivotal role of TLR2 and TLR4 has been recognized in atherogenesis. We investigated the effect of simvastatin monotherapy or its combination with ezetimibe on TLR2 an
Autor:
Murat Tuzcu, Mohamed B. Elshazly, Stephen J. Nicholls, Samir R. Kapadia, Steven E. Nissen, Leslie Cho, Brian Stegman, Rishi Puri, Peta King, Mingyuan Shao
Publikováno v:
Atherosclerosis. 254
High-intensity statin therapy (HIST) reduces cardiovascular events, however, sex-related differences in treatment effects are not well characterized.A patient-level post hoc pooled analysis of 3 randomized trials utilizing serial coronary intravascul
Autor:
Miao Hu, Brian Tomlinson
Publikováno v:
Atherosclerosis. 223:427-432
Objectives In vitro and animal studies showed that statins could increase bilirubin levels by activation of haem oxygenase-1, whereas the effect of statins on serum bilirubin levels in humans remains controversial. The organic anion transporting poly
Autor:
Elise F. Villard, Natalie Fournier, Petra El Khoury, Emilie Duchene, Zélie Julia, Maryse Guerin, Wilfried Le Goff, M. John Chapman, Natacha Bellanger
Publikováno v:
Atherosclerosis. 221:160-168
Objective To evaluate the impact of CETP inhibition on the capacity of individual postprandial HDL subspecies to promote key steps of the reverse cholesterol transport pathway. Methods The capacity of HDL particles to mediate cellular free cholestero
Autor:
Ivor B. Asztalos, Fumiyoshi Tsunoda, Katalin V. Horvath, Ernst J. Schaefer, Bela F. Asztalos, George Steiner
Publikováno v:
Atherosclerosis. 247
Background There are conflicting reports on the role of fibrates in CVD-risk. Several studies indicate beneficial effects of fibrates on CVD risk in type-2 diabetic patients. We tested how fenofibrate changes lipoprotein subfractions and glucose home
Autor:
James P. Corsetti, Arthur J. Moss, Wojciech Zareba, Charles E. Sparks, Daniel H. Ryan, Peter Salzman
Publikováno v:
Atherosclerosis. 250
Background and aims Evidence continues to accumulate that athero-protective effects of high-density lipoprotein (HDL) depend to some degree on effective HDL functionality and that such functionality can become degraded in the setting of chronic infla
Autor:
Renate Koppensteiner, Cihan Ay, Thomas Gremmel, Sabine Steiner, Daniela Seidinger, Christine Mannhalter, Simon Panzer, Christoph W. Kopp
Publikováno v:
Atherosclerosis. 217:135-138
To investigate the interrelation between the P-selectin gene (SELP) Pro715 allele, P2Y12 adenosine diphosphate (ADP) receptor reactivity and levels of soluble P-selectin (sP-selectin) in clopidogrel treated patients.The Pro715 allele within SELP was
Publikováno v:
Atherosclerosis. 213:218-224
Background The effect of atorvastatin on kidney function was assessed in patients with stages 2-4 chronic kidney disease. Methods We conducted a randomised, double-blind, placebo-controlled trial in chronic kidney disease clinics in Northern Tasmania