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Publikováno v:
Atherosclerosis
Background and aims We have shown previously that low density lipoprotein (LDL) aggregated by vortexing is internalised by macrophages and oxidised by iron in lysosomes to form the advanced lipid/protein oxidation product ceroid. We have now used sph
Overexpression of perilipin1 protects against atheroma progression in apolipoprotein E knockout mice
Autor:
Tatsuya Atsumi, Akinobu Nakamura, Hideaki Miyoshi, Kyu Yong Cho, Kohei Yamamoto, Andrew S. Greenberg
Publikováno v:
Atherosclerosis. 269:192-196
Background and aims: Perilipin1 (PLIN1), a lipid droplet-associated protein, plays an important role in the regulation of lipolysis and lipid storage in adipocytes. PLIN1 has recently been reported to be expressed in macrophages within atheroma plaqu