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Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 4, Pp 419-431 (2021)
Curcumin and its derivatives have good electrical and optical properties due to the highly symmetric structure of delocalized π electrons. Apart from that, curcumin and its derivatives can interact with numerous molecular targets, thereby exerting l
Autor:
Dan Chen, Tiantian Tan, Jiaxing Feng, Juan Zhao, Xu Song, Yao Fu, Ling Xiang, Qin Yang, Tao Gong
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 4, Pp 508-518 (2021)
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences
Chondroitin sulfate-mediated albumin corona nanoparticles were readily prepared without any chemical reaction, and their active tumor targeting and therapeutic effects were examined. Negatively charged chondroitin sulfate (CS) and positively charged
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 3, Pp 387-395 (2021)
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences
Most biopharmaceutics classification system (BCS) class IV drugs, with poor solubility and inferior permeability, are also substrates of P-glycoprotein (P-gp) and cytochrome P450 (CYP450), leading to their low oral bioavailability. The objective of t
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 3, Pp 363-373 (2021)
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences
TPGS approved by FDA can be used as a P-gp inhibitor to effectively reverse multi-drug resistance (MDR) and as an anticancer agent for synergistic antitumor effects. However, the comparatively high critical micelle concentration (CMC), low drug loadi
Autor:
Fumei He, Gan Liu, Lin Mei, Ke Cheng, Jingxiu Cao, Yue Xiong, Qi Huang, Wenbin Deng, Junyang Qi
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 2, Pp 222-235 (2021)
Black phosphorus (BP) nano-materials, especially BP quantum dots (BPQDs), performs outstanding photothermal antitumor effects, excellent biocompatibility and biodegradability. However, there are several challenges to overcome before offering real ben
Autor:
Minghui Li, Ge Song, Mengmeng Qin, Dakuan Wang, Qiang Zhang, Bing He, Hailiang Deng, Xueqing Wang, Wenbing Dai, Hua Zhang
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 16, Iss 1, Pp 97-109 (2021)
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences
Currently, the cancer immunotherapy has made great progress while antitumor vaccine attracts substantial attention. Still, the selection of adjuvants as well as antigens are always the most crucial issues for better vaccination. In this study, we pro
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 15, Iss 6, Pp 752-758 (2020)
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences
The absorption of peptides and proteins delivered orally is minimum because of the intestine epithelial barrier. There are few known active transport mechanisms for macromolecules including the neonatal Fc Receptor (FcRn) for the absorption and secre
Autor:
Kaiyuan Wang, Lin Wei, Haotian Zhang, Hang Song, Xuanbo Zhang, Yusheng Wu, Shuang Zhou, Na Li, Tao Jin, Jin Sun, Qiming Kan, Shenwu Zhang, Bin Ji, Yuequan Wang, Xiaohui Yao, Bin Yang
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 15, Iss 5, Pp 637-645 (2020)
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences
One of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in tumors. Tumor cells generally display the higher oxidative level than normal cells, and also displayed the heterogeneity in terms of
Autor:
Jiucun Chen, Xiaohua Huang, Tian Zhang, Die Jia, Xiaoli Zhang, Feiqiu Wen, Yi Lu, Xianbin Ma, Yajun Wang, Zhigang Xu
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 15, Iss 5, Pp 605-616 (2020)
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences
Tumor cells show acidic conditions compared with normal cells, which further inspires scientist to build nanocarrier responsive to tumor microenvironment (TME) for enhancing tumor therapeutic efficacy. Here, we report a pH-sensitive and biocompatible
Autor:
Heba Elmotasem, Ghada E.A. Awad
Publikováno v:
Asian Journal of Pharmaceutical Sciences, Vol 15, Iss 5, Pp 617-636 (2020)
Asian Journal of Pharmaceutical Sciences
Asian Journal of Pharmaceutical Sciences
Fungal keratitis and endopthalmitis are serious eye diseases. Fluconazole (FL) is indicated for their treatment, but suffers from poor topical ocular availability. This study was intended to improve and prolong its ocular availability. FL niosomal ve