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Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-19 (2019)
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-19 (2019)
Background CD38+ NK cells are overabundant in rheumatoid arthritis (RA). Cyanidin-3-O-glucoside (C3G) is an inhibitor of CD38. This study investigated the pathogenic role of CD38+ NK cells and the effect of C3G on RA. Methods Rats with bovine type II
Autor:
Benjamin D. Korman, Warren G. Tourtellotte, Jerrold M. Olefsky, Gabriel Lord, John Varga, Roberta Goncalves Marangoni
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-11 (2018)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background A pivotal role for adipose tissue homeostasis in systemic sclerosis (SSc) skin fibrosis is increasingly recognized. The nuclear receptor PPAR-γ is the master regulator of adipogenesis. Peroxisome proliferator activated receptor-γ (PPAR-
Autor:
Falk Moritz, Janine Schniering, Jörg H. W. Distler, Renate E. Gay, Steffen Gay, Oliver Distler, Britta Maurer
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-11 (2017)
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-11 (2017)
Background The angiopoietin(Ang)/Tie2 system is a key regulator of vascular biology. The expression of membrane bound (mb) Tie2 and Ang-1 ensures vessel stability, whereas Ang-2, inducible by vascular endothelial growth factor (VEGF), hypoxia, and in