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Autor:
Jasmin D. Tran, Anthony E. Bishay, Eduardo Monarrez, Richard E. Hartman, Maximillian E. Denys, Valeria Carrillo, Syed A. Uddin, Karl-Werner Schramm, Gregory Lampel, Julia M. Krum, Bernhard Henkelmann, Elena V. Kozlova, Prasada Rao S. Kodavanti, Margarita C. Currás-Collazo, Allison L. Phillips, Duraan S. Olomi, Nicole M. Huffman, Matthew Valdez, Brigitte M. Vazquez, Laura M. Anchondo, Heather M. Stapleton, Gladys Chompre, Bhuvaneswari D. Chinthirla, Kayhon M. Rabbani, Gwendolyn Gonzalez
Publikováno v:
Archives of Toxicology
Arch. Toxicol., DOI: 10.1007/s00204-021-03163-4 (2021)
Arch. Toxicol., DOI: 10.1007/s00204-021-03163-4 (2021)
Polybrominated diphenyl ethers (PBDEs) are ubiquitous persistent organic pollutants (POPs) that are known neuroendocrine disrupting chemicals with adverse neurodevelopmental effects. PBDEs may act as risk factors for autism spectrum disorders (ASD),
Publikováno v:
Archives of Toxicology
Intake of synthetic cannabinoids (SC), one of the largest classes of new psychoactive substances, was reported to be associated with acute liver damage but information about their hepatotoxic potential is limited. The current study aimed to analyze t
Autor:
Walter K. Schlage, Julia Hoeng, Dariusz Peric, Nicolas Sierro, John H. Miller, Ee Tsin Wong, Blaine Phillips, Justyna Szostak, Jingjie Zhang, Emmanuel Guedj, Patrick Vanscheeuwijck, Jovan Simicevic, Tom Lee, Manuel C. Peitsch, Patrice Leroy, Remi Dulize, Maica Corciulo, Oksana Lavrynenko, Yang Xiang, Kyeonghee Monica Lee, David Bornand, Bjoern Titz, Sin Kei Wong, Karsta Luettich, Mohamed Amin Choukrallah, Arkadiusz K. Kuczaj, Guo Jie Loh, Thomas Schneider, Nikolai V. Ivanov, Mehdi Auberson, Celine Merg, Ansgar Buettner
Publikováno v:
Archives of Toxicology
Cigarette smoking is the major cause of chronic obstructive pulmonary disease. Considerable attention has been paid to the reduced harm potential of nicotine-containing inhalable products such as electronic cigarettes (e-cigarettes). We investigated
Autor:
Peter H. Schmidt, Christina Körbel, Nadine Schaefer, Hans H. Maurer, Markus R. Meyer, Matthias W. Laschke, Frederike Nordmeier, Ann-Katrin Kröll, Michael D. Menger
Publikováno v:
Archives of Toxicology
Examining fatal poisonings, chronic exposure may be reflected by the concentration in tissues known for long-term storage of drugs. Δ9-tetrahydrocannabinol (THC) persists in adipose tissue (AT), but sparse data on synthetic cannabinoids (SC) are ava
Publikováno v:
Archives of Toxicology
Organophosphorus (OP) pesticides and nerve agents still pose a threat to the population. Treatment of OP poisoning is an ongoing challenge and burden for medical services. Standard drug treatment consists of atropine and an oxime as reactivator of OP
Autor:
Ee Tsin Wong, Victor Häussling, Patrice Leroy, Bjoern Titz, Manuel C. Peitsch, Romina H. Aspera-Werz, Wei Teck Tan, Justyna Szostak, Andreas K. Nussler, Christof Audretsch, Julia Hoeng, Peter Augat, Jenny Schaefer, Fabian Springer, K. Monica Lee, Arkadiusz K. Kuczaj, Marie K. Reumann, Sabrina Ehnert, Leticia Quentanilla-Fend, Manuela Martella, Andreas Badke
Publikováno v:
Archives of Toxicology
Cigarette smoke (CS) exposure is one of the leading risk factors for human health. Nicotine-containing inhalable products, such as e-cigarettes, can effectively support tobacco harm reduction approaches. However, there are limited comparative data on
Autor:
Bhavik Chouhan, Dominic P. Williams, Magnus Söderberg, James W. Dear, Catherine C. Bell, Håkan Andersson, Linda C. Andersson
Publikováno v:
Archives of Toxicology
Bell, C C, Chouhan, B, Andersson, L C, Andersson, H, Dear, J, Williams, D P & Soderberg, M 2020, ' Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity. ', Archives of toxicology . https://doi.org/10.1007/s00204-020-02682-w)
Bell, C C, Chouhan, B, Andersson, L C, Andersson, H, Dear, J, Williams, D P & Soderberg, M 2020, ' Functionality of primary hepatic non-parenchymal cells in a 3D spheroid model and contribution to acetaminophen hepatotoxicity. ', Archives of toxicology . https://doi.org/10.1007/s00204-020-02682-w)
In addition to hepatocytes, the liver comprises a host of specialised non-parenchymal cells which are important to consider in the development of in vitro models which are both physiologically and toxicologically relevant. We have characterized a 3D
Autor:
Michel Eichelbaum, Astrid Nörenberg, Maria Thomas, Ulrich M. Zanger, Werner Schroth, Thomas E. Mürdter, Hiltrud Brauch, Matthias Schwab, Janina Johänning, Patrick Kröner
Publikováno v:
Archives of Toxicology
Tamoxifen, a standard therapy for breast cancer, is metabolized to compounds with anti-estrogenic as well as estrogen-like action at the estrogen receptor. Little is known about the formation of estrogen-like metabolites and their biological impact.
Autor:
Alec T. Salminen, William B. Mattes, William F. Salminen, Thomas Papoian, Lijun Ren, Yong Luo, Matthew White, Xi Yang, Qiangen Wu, Qiang Shi, Jun Zhang, Matthew Bryant, James Greenhaw
Publikováno v:
Archives of Toxicology
The FDA has approved 31 small-molecule kinase inhibitors (KIs) for human use as of November 2016, with six having black box warnings for hepatotoxicity (BBW-H) in product labeling. The precise mechanisms and risk factors for KI-induced hepatotoxicity
Autor:
Pritmohinder S. Gill, Xi Yang, Laura K. Schnackenberg, Jinchun Sun, Richard D. Beger, Laura P. James, Sudeepa Bhattacharyya
Publikováno v:
Archives of Toxicology
Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactiv