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Autor:
Jasmin D. Tran, Anthony E. Bishay, Eduardo Monarrez, Richard E. Hartman, Maximillian E. Denys, Valeria Carrillo, Syed A. Uddin, Karl-Werner Schramm, Gregory Lampel, Julia M. Krum, Bernhard Henkelmann, Elena V. Kozlova, Prasada Rao S. Kodavanti, Margarita C. Currás-Collazo, Allison L. Phillips, Duraan S. Olomi, Nicole M. Huffman, Matthew Valdez, Brigitte M. Vazquez, Laura M. Anchondo, Heather M. Stapleton, Gladys Chompre, Bhuvaneswari D. Chinthirla, Kayhon M. Rabbani, Gwendolyn Gonzalez
Publikováno v:
Archives of Toxicology
Arch. Toxicol., DOI: 10.1007/s00204-021-03163-4 (2021)
Arch. Toxicol., DOI: 10.1007/s00204-021-03163-4 (2021)
Polybrominated diphenyl ethers (PBDEs) are ubiquitous persistent organic pollutants (POPs) that are known neuroendocrine disrupting chemicals with adverse neurodevelopmental effects. PBDEs may act as risk factors for autism spectrum disorders (ASD),
Autor:
Alec T. Salminen, William B. Mattes, William F. Salminen, Thomas Papoian, Lijun Ren, Yong Luo, Matthew White, Xi Yang, Qiangen Wu, Qiang Shi, Jun Zhang, Matthew Bryant, James Greenhaw
Publikováno v:
Archives of Toxicology
The FDA has approved 31 small-molecule kinase inhibitors (KIs) for human use as of November 2016, with six having black box warnings for hepatotoxicity (BBW-H) in product labeling. The precise mechanisms and risk factors for KI-induced hepatotoxicity
Autor:
Pritmohinder S. Gill, Xi Yang, Laura K. Schnackenberg, Jinchun Sun, Richard D. Beger, Laura P. James, Sudeepa Bhattacharyya
Publikováno v:
Archives of Toxicology
Acetaminophen (APAP) is a commonly used analgesic drug that can cause liver injury, liver necrosis and liver failure. APAP-induced liver injury is associated with glutathione depletion, the formation of APAP protein adducts, the generation of reactiv