Zobrazeno 1 - 10
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Autor:
ChenAlice, PaffenrothElizabeth, NoronaLeah, HanumegowdaUmesh, CarterDwayne, PresnellSharon, RettingKelsey, Crogan-GrundyCandace, HazelwoodLisa, KhatiwalaChirag, Lehman-McKeemanLois
Publikováno v:
Applied In Vitro Toxicology. 4:288-303
The rapid advancement of additive manufacturing technologies and their extension into biological systems have led to the emergence of a new category of cell-based models, namely bioprinted...
Autor:
E M VickersAlison, L FisherRobyn
Publikováno v:
Applied In Vitro Toxicology. 4:280-287
Introduction: Liver organ slices are a multicellular three-dimensional tissue model, relevant for defining the dose–response profile of drug-induced injury, and for demonstrating which is ...
Autor:
H BenamKambez
Publikováno v:
Applied In Vitro Toxicology. 4:107-114
Cigarette smoking is major public health problem and a substantial contributor to the pathogenesis of respiratory disorders such as chronic obstructive pulmonary disease and lung cancer. In addition, our society faces the rapidly growing use of tobac
Autor:
Samantha C. Faber, Shaun D. McCullough
Publikováno v:
Applied In Vitro Toxicology. 4:115-128
With 7 million deaths reported annually from air pollution alone, it is evident that adverse effects of inhaled toxicant exposures remain a major public health concern in the 21st century. Assessment and characterization of the impacts of air polluta
Autor:
Lisa Fredriksson, Claudia Escher, Katrin Roessger, Magdalena Bober, Simon Messner, Volker M. Lauschke, Magnus Ingelman-Sundberg, Wolfgang Moritz, Jens M. Kelm
Publikováno v:
Applied in Vitro Toxicology
Three-Dimensional (3D) liver microtissues, specifically prepared from primary human hepatocytes (PHH) in coculture with nonparenchymal cells (NPCs), have been shown to be a valuable tool for in vitro toxicology. However, a lack of thorough characteri
Autor:
LuijtenMirjam, T M van der VenLeo, van den BrandhofEvert-Jan, RuiterSander, M HodemaekersHennie, L A PenningsJeroen, JelinekJaroslav, P ZwartEdwin, J IssaJean-Pierre
Publikováno v:
Applied In Vitro Toxicology. 3:312-324
There is a need to identify processes underlying development of chemically induced chronic disease in humans, preferably describing key events and their relationships in an adverse outcome pathway (AOP) analysis. Epigenetic modifications, and particu
Autor:
P WitekRafal, A BonzoJessica
Publikováno v:
Applied In Vitro Toxicology. 4:229-231
Autor:
TaylorMark, CorkeSarah, OkeOluwatobiloba, HewittKatherine, Foss-SmithGeoff, CockcroftNatalia, LoweFrazer, CarrTony, AzzopardiDavid
Publikováno v:
Applied In Vitro Toxicology. 3:182-192
Assessment of novel tobacco and nicotine products for their harm reduction potential compared with cigarettes is of significance for regulators and public health. The National Research Council's report, “Toxicity Testing in the 21st Century,” out
Autor:
C PeitschManuel, V IvanovNikolai, AcaliStefano, DulizeRemi, PericDariusz, MarescottiDiego, ScottiElena, Gonzalez-SuarezIgnacio, MartinFlorian, GuedjEmmanuel, FrentzelStefan, HoengJulia, BaumerKarine
Publikováno v:
Applied In Vitro Toxicology. 3:41-55
Electronic nicotine delivery systems (ENDS) dispense nicotine by heating a solution (e-liquid) and generating an aerosol that is then inhaled by the user. ENDS have been previously reported by some as less harmful than conventional cigarettes. Howeve
Autor:
CorkeSarah, AdamsonJason, ThorneDavid, E HaswellLinsey, AzzopardiDavid, BanerjeeAnisha, BaxterAndrew, D GacaMarianna, MinetEmmanuel, ParmarAleesha, MushonganonoJessica
Publikováno v:
Applied In Vitro Toxicology. 3:84-98
The use of electronic cigarettes (e-cigarettes) potentially offers a safer alternative to conventional tobacco products. The advance in molecular biology and computational sciences offers new perspective to assess adverse biological responses for pro