Zobrazeno 1 - 10
of 32
pro vyhledávání: ''
Publikováno v:
APMIS. 128:543-551
The Hippo pathway is a tumor suppressive pathway regulating Yes-associated protein-TEA domain-containing sequence-specific transcription factor (YAP-TEAD) complex. VGLL (Vestigial-like) proteins are transcriptional cofactors competing with YAP for TE
Autor:
Anne Tuomisto, Jyrki Mäkelä, Taneli Mattila, Madhura Patankar, Tuomo J. Karttunen, Kai Klintrup, Markus J. Mäkinen, Juha P. Väyrynen, Pentti Nieminen
Publikováno v:
APMIS. 128:390-400
Anoikis is a form of apoptosis induced when a cell loses contact with the extracellular matrix (ECM). Anoikis resistance is essential for metastasis formation, yet only detectable by in vitro experiments. We present a method for quantitation of putat
Autor:
Thiago Xavier Carneiro, Igor Allen Sousa Frederico, Eduardo Henrique Cunha Neves Filho, Rommel Mario Rodriguez Burbano, Silvia Helena Barem Rabenhorst, Carlos Gustavo Hirth
Publikováno v:
APMIS. 128:308-315
EZH2 is an important epigenetic regulator, but its role in diffuse large B-cell lymphoma (DLBCL) pathogenesis and its relationship with MYC, BCL2, and TP53 expression, chromosomal rearrangements, and clinical features are still poorly understood. So,
Autor:
Faruk Skenderi, Ljiljana Šerman, Alan Šerman, Tamara Nikuševa-Martić, Ida Marija Sola, Vedran Kardum, Semir Vranic, Valentina Karin-Kujundzic, Frane Paić, Anita Škrtić
Publikováno v:
APMIS. 128:201-210
Dishevelled family proteins (DVL1, DVL2 and DVL3) are cytoplasmic mediators involved in canonical and non-canonical Wnt signaling that are important for embryonic development. Since Wnt signaling promotes cell proliferation and invasion, its increase
Autor:
Haeryoung Kim, Jaihwan Kim, Yu Jung Kim, Yoo Seok Yoon, YoungRok Choi, Jin Won Kim, Keun Wook Lee, Jin-Hyeok Hwang, Ho-Seong Han, Ji Won Kim, Sehhoon Park, Jee Hyun Kim, Jai Young Cho
Publikováno v:
APMIS. 125:699-707
Resectable pancreatic cancer has a high recurrence rate after curative surgery. Biomarkers are needed for distinguishing patients who may benefit from curative resection. In this study, we sought to analyze the prognostic value of p21-activated kinas
Publikováno v:
APMIS. 123:823-831
Epidermal growth factor receptor system plays a central hepato-protective and pro-regenerative role in liver. Transforming growth factor-α (TGF-α) is an important autocrine growth regulator of hepatocytes that plays a role in development of hepatoc
Autor:
Morten Grauslund, Simon Andreasen, Marianne Hamilton Therkildsen, Lennart Friis-Hansen, Preben Homøe, Irene Wessel
Publikováno v:
APMIS. 123:706-715
The interleukin-6 (IL-6)/Janus kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway is of crucial importance in promoting tumorigenesis in several malignant tumors but may also be active in benign tumors, e.g., of pleomorph
Publikováno v:
APMIS. 122:867-872
Anaplastic lymphoma kinase (ALK) gene aberrations are found in several tumor types including anaplastic large cell lymphoma (ALCL) and non-small cell lung cancer (NSCLC). Crizotinib, an inhibitor of ALK-fusion proteins, has shown clinical activity, b
Autor:
Sun Young Kwon, Woo Jin Chung, Dong Choon Kim, Koo Jeong Kang, Byung Kuk Jang, Jae Seok Hwang, Jae-Ho Lee
Publikováno v:
APMIS. 122:1001-1006
Hepatocellular carcinoma (HCC) is the fourth most common form of cancer in the Korean population, caused primarily by infection with either the Hepatitis B or C virus. Progression of this disease is frequently associated with mutations in either phos
Autor:
Katharina L. Kopp, Boye Schnack Nielsen, Ulrik Ralfkiaer, Elisabeth Ralfkiaer, Robert Gniadecki, Anders Woetmann, Niels Ødum
Publikováno v:
APMIS. 121:1020-1024
Recently, miR-155 has been implicated in cutaneous T-cell lymphoma (CTCL). Thus, elevated levels of miR-155 were observed in skin lesions from CTCL patients as judged from qPCR and micro-array analysis and aberrant, high miR-155 expression was associ