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Publikováno v:
Antioxidants & Redox Signaling
Significance: Magnetic resonance imaging (MRI) with hyperpolarized (HP) 13C-labeled redox-sensitive metabolic tracers can provide noninvasive functional imaging biomarkers, reflecting tissue redox state, oxidative stress, and inflammation, among othe
Autor:
Vivien Pósa, Veronika F.S. Pape, Nikolett Jabronka, Éva A. Enyedy, Bianca Montsch, Lukas Uhlik, Sonja Hager, Bernhard K. Keppler, Szilárd Tóth, Christian R. Kowol, Petra Heffeter, Gergely Szakács
Publikováno v:
Antioxidants & Redox Signaling. 33:395-414
Aims: Due to their significant biological activity, thiosemicarbazones (TSCs) are promising candidates for anticancer therapy. In part, the efficacy of TSCs is linked to their ability to chelate essential metal ions such as copper and iron. Triapine,
Autor:
Angela Fago, Birgitte Geert Jensen
Publikováno v:
Jensen, B & Fago, A 2020, ' A Novel Possible Role for Met Hemoglobin as Carrier of Hydrogen Sulfide in the Blood ', Antioxidants & Redox Signaling, vol. 32, no. 4, pp. 258-265 . https://doi.org/10.1089/ars.2019.7877
Significance: Along with other gasotransmitters nitric oxide (NO) and carbon monoxide, hydrogen sulfide (H2S) has recently emerged as an important signaling molecule with a particularly complex metabolism. Endogenous H2S reacts with multiple cellular
Autor:
John S. Olson
Publikováno v:
Antioxidants & Redox Signaling. 32:228-246
Significance: Over the past 50 years, the mechanisms for O(2) storage and transport have been determined quantitatively on distance scales from millimeters to tenths of nanometers and timescales from seconds to picoseconds. Recent Advances: In this r
Autor:
Brian Deng, Natalia Kyui, Júlio S. Rebouças, Margaret E. Tome, Artak Tovmasyan, Ting-Ting Huang, Melba C. Jaramillo, Romulo S. Sampaio, Jacqueline C. Bueno-Janice, Ivan Spasojevic, Ines Batinic-Haberle, Ludmil Benov
Publikováno v:
Antioxidants & Redox Signaling. 29:1196-1214
Aims: We aim here to demonstrate that radiation (RT) enhances tumor sensitization by only those Mn complexes that are redox active and cycle with ascorbate (Asc), thereby producing H(2)O(2) and utilizing it subsequently in protein S-glutathionylation
Autor:
Monika Bozem, Ivan Bogeski, Phillip Knapp, Markus Hoth, Christian Heinemann, Reinhard Kappl, Ewa J. Slowik, Valentin Mirčeski
Publikováno v:
Antioxidants & Redox Signaling
Aims: H2O2 is produced by all eukaryotic cells under physiological and pathological conditions. Due to its enormous relevance for cell signaling at low concentrations and antipathogenic function at high concentrations, precise quantification of extra
Publikováno v:
Antioxidants & Redox Signaling. 29:471-483
Aim: In this study, we tested the hypothesis that lipid peroxide-derived dicarboxylic acids (DCAs), by virtue of their ability to bind to calcium (Ca), might be involved in atherosclerotic calcification. We determined the ability of azelaic acid (AzA
Autor:
Alexander S. Keller, Brant E. Isakson
Publikováno v:
Antioxidants & Redox Signaling. 26:881-885
Heterocellular communication between different cell types of the vasculature, both within the blood vessel wall and cells interacting with the blood vessel wall, is absolutely vital and must be tightly regulated. In this Forum, the role of four diffe
Publikováno v:
Antioxidants & Redox Signaling. 26:107-121
Soluble guanylyl/guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) and is central to the physiology of blood pressure regulation, wound healing, memory formation, and other key physiological activities. sGC is increasingly implica
Autor:
Hideo Kimura
Publikováno v:
Antioxidants & Redox Signaling. 27:619-621
Hydrogen sulfide (H2S) has been demonstrated to have physiological roles such as neuromodulation, vascular tone regulation, cytoprotection, oxygen sensing, inflammatory regulation, and cell growth. Recently, hydrogen polysulfides (H2Sn) have been fou