Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Mark A Wainberg"'
Autor:
Mark A. Wainberg, Bluma G. Brenner, Maureen Oliveira, Hongtao Xu, Nathan Osman, Simrat Bharaj, Thibault Mesplède, Ahmad Alikhani, Said Hassounah, Ruxandra-Ilinca Ibanescu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
Animal models are essential to study novel antiretroviral drugs, resistance-associated mutations (RAMs), and treatment strategies. Bictegravir (BIC) is a novel potent integrase strand transfer inhibitor (INSTI) that has shown promising results agains
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:310-316
Clinical studies have shown that integrase strand transfer inhibitors (INSTIs) can be used effectively against HIV-1 infection. To date, no resistance substitution has been found in INSTI-naive patients treated with the new integrase inhibitor dolute
Autor:
Bluma G. Brenner, Agnès Depatureaux, Hannah Koubi, Daniela Moisi, Mark A. Wainberg, Thibault Mesplède, Peter K. Quashie, Maureen Oliveira, Ying-Shan Han, Jean-Christophe Plantier
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:7141-7150
HIV-1 group O (HIV-O) is a rare HIV-1 variant characterized by a high number of polymorphisms, especially in the integrase coding region. As HIV-O integrase enzymes have not previously been studied, our aim was to assess the impact of HIV-O integrase
Autor:
Susan P. Colby-Germinario, Maureen Oliveira, Hongtao Xu, Daniel Rajotte, Richard Bethell, Mark A. Wainberg
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:4515-4526
A W153L substitution in HIV-1 reverse transcriptase (RT) was recently identified by selection with a novel nucleotide-competing RT inhibitor (NcRTI) termed compound A that is a member of the benzo[4,5]furo[3,2,d]pyrimidin-2-one NcRTI family of drugs.
Autor:
Guojun Wu, Xiaojian Yao, Shuiping Liu, Liyu Chen, Gary P. Kobinger, Mark A. Wainberg, Zhujun Ao, Kallesh Danappa Jayappa
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3547-3554
In the absence of an effective vaccine against HIV-1 infection, anti-HIV-1 strategies play a major role in disease control. However, the rapid emergence of drug resistance against all currently used anti-HIV-1 molecules necessitates the development o
Autor:
Susan M. Schader, Mark A. Wainberg, Eugene L. Asahchop, Susan P. Colby-Germinario, Hongtao Xu, Maureen Oliveira, Matthew McCallum, Stefan G. Sarafianos, Yudong Quan, Ying-Shan Han
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3100-3109
Impacts of mutations at position E138 (A/G/K/Q/R/V) alone or in combination with M184I in HIV-1 reverse transcriptase (RT) were investigated. We also determined why E138K is the most prevalent nonnucleoside reverse transcriptase inhibitor mutation in
Autor:
Daniel A. Donahue, Maureen Oliveira, Randy Tressler, Susan M. Schader, Diane N. Singhroy, Richard D Sloan, Mark A. Wainberg, Susan P. Colby-Germinario, Victor G. Kramer
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:4154-4160
HIV entry inhibitors, such as maraviroc (MVC), prevent cell-free viruses from entering the cells. In clinical trials, patients who were treated with MVC often displayed viral loads that were above the limit of conventional viral load detection compar
Autor:
Thibault Mesplède, Susan P. Colby-Germinario, Mark A. Wainberg, Susan M. Schader, Maureen Oliveira, Daniela Moisi, Peter K. Quashie, Ruxandra-Ilinca Ibanescu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:4257-4267
BMS-599793 is a small molecule entry inhibitor that binds to human immunodeficiency virus type 1 (HIV-1) gp120, resulting in the inhibition of CD4-dependent entry into cells. Since BMS-599793 is currently considered a candidate microbicide drug, we e
Autor:
Maureen Oliveira, Susan P. Colby-Germinario, Susan M. Schader, Daniela Moisi, Mark A. Wainberg, Ruxandra-Ilinca Ibanescu
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:751-756
Antiretroviral-based microbicides may offer a means to reduce the sexual transmission of HIV-1. Suboptimal use of a microbicide may, however, lead to the development of drug resistance in users that are already, or become, infected with HIV-1. In suc
Autor:
Bluma G. Brenner, Maureen Oliveira, Mark A. Wainberg, Eugene L. Asahchop, Cécile Tremblay, Thomas d'Aquin Toni, Daniela Moisi
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:600-607
We have selected for resistance to etravirine (ETR) and efavirenz (EFV) in tissue culture using three subtype B, three subtype C, and two CRF02_AG clinical isolates, grown in cord blood mononuclear cells. Genotypic analysis was performed at baseline