Zobrazeno 81 - 90
of 160
pro vyhledávání: '"11"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 39:1107-1113
The frequency of trypanosomes resistant to diminazene aceturate at a dose of 25 mg/kg of body weight was investigated for populations of Trypanosoma congolense IL 3274 which reappeared in infected mice after intraperitoneal treatment with diminazene
Publikováno v:
Antimicrobial agents and chemotherapy. 56(10)
The pharmacodynamics (PD) of voriconazole activity against Aspergillus spp. were studied using a new in vitro dynamic model simulating voriconazole human pharmacokinetics (PK), and the PK-PD data were bridged with human drug exposure to assess the pe
Autor:
Stefan Weiler, Eva Stienecke, Stefan Dunzendorfer, Julia Schöfmann, Elisabeth Überlacher, Romuald Bellmann, Michael Joannidis
Publikováno v:
Antimicrobial agents and chemotherapy. 56(10)
The pharmacokinetics of lipid-bound and liberated amphotericin B (AMB) was assessed in 11 critically ill patients with cholestatic liver disease (CSLD) and in 9 subjects with normal liver function treated with AMB colloidal dispersion (ABCD). Exposur
Autor:
Andrea L. Kwa, William W. Hope, Ben M. Lomaestro, Thomas P. Lodise, Jill M. Butterfield, Timothy Felton, George L. Drusano
Publikováno v:
Antimicrobial agents and chemotherapy. 56(8)
While extended infusions of piperacillin-tazobactam (TZP) are increasingly used in practice, the effect of infusion on the pharmacokinetic (PK) profile of TZP has not been widely assessed. To assess its effect on the pharmacokinetic profile of TZP, s
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:2024-2028
The objective of the reported study was to characterize the pharmacokinetics of ticarcillin and clavulanic acid in premature low-birth-weight (less than 2,200 g) neonates with presumed sepsis. Eleven infants received 12 courses of ticarcillin-clavula
Autor:
Louis Grenier, Denis Beauchamp, Marie Simard, Michel G. Bergeron, Yves Bergeron, Gaston Labrecque, Lesheng Lin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:54-60
The present study was designed to determine the temporal changes in tobramycin nephrotoxicity during the dark and the light periods of the day and to look for the mechanisms of such changes. Female Sprague-Dawley rats (9 to 11 weeks old) were housed
Autor:
Randall K. Nakahiro, Peter N.R. Heseltine, J. Farino, Mark A. Gill, Albert E. Yellin, Thomas V. Berne, Mark P. Okamoto, A. Bedikian, Maria D. Appleman
Publikováno v:
Antimicrobial Agents and Chemotherapy. 38:151-154
Noncompartmental and compartmental analyses of meropenem disposition in patients receiving 1-g intravenous intermittent infusions every 8 h were performed. Twelve patients (one woman and 11 men) participated in the meropenem pharmacokinetic analysis.
Publikováno v:
Antimicrobial agents and chemotherapy. 56(2)
Lopinavir exposure was reduced during the third trimester in pregnant women receiving standard dosing of the soft-gel capsule (SGC; 400/100 mg twice daily [b.i.d.]). Pharmacokinetic data on the lopinavir tablet in pregnancy are limited. On the basis
Autor:
Hanna E. Sidjabat, David L. Paterson, Alan Forrest, Roger L. Nation, Jovan Jacob, Phillip J. Bergen, Brian T. Tsuji, Jian Li, Jürgen B. Bulitta
Publikováno v:
Antimicrobial agents and chemotherapy. 55(12)
Combination therapy may be required for multidrug-resistant (MDR) Pseudomonas aeruginosa . The aim of this study was to systematically investigate bacterial killing and emergence of colistin resistance with colistin and doripenem combinations against
Autor:
Karen T. Tashima, Pamela Poethke, Julie B. Dumond, Awewura Kwara, Jaclyn Kurpewski, Angela D. M. Kashuba, David J. Greenblatt, Michael H. Court
Publikováno v:
Antimicrobial agents and chemotherapy. 55(7)
Efavirenz-based antiretroviral regimen is preferred during rifampin-containing tuberculosis therapy. However, current pharmacokinetic data are insufficient to guide optimized concurrent dosing. This study aimed to better characterize the effects of r