Zobrazeno 31 - 40
of 160
pro vyhledávání: '"11"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:2078-2085
Isavuconazole is a novel broad-spectrum triazole antifungal agent. This open-label dose escalation study assessed the safety and pharmacokinetics of intravenous isavuconazole prophylaxis in patients with acute myeloid leukemia who had undergone chemo
Autor:
Marc H Weiner, Kelly E. Dooley, Thuy Hoang, William R. Mac Kenzie, Susan E. Dorman, Erin Bliven-Sizemore, Teresa L. Parsons, Mark A. Marzinke
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:6747-6757
The quantification of antituberculosis drug concentrations in multinational trials currently requires the collection of modest blood volumes, centrifugation, aliquoting of plasma, freezing, and keeping samples frozen during shipping. We prospectively
Autor:
Mohammed H. Elkomy, Adam L. Hersh, Krisa P. Van Meurs, Adam Frymoyer, Shabnam Gaskari, David R. Drover, Felice Su
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:6454-6461
National treatment guidelines for invasive methicillin-resistant Staphylococcus aureus (MRSA) infections recommend targeting a vancomycin 24-h area under the concentration-time curve (AUC 0–24 )-to-MIC ratio of >400. The range of vancomycin trough
Autor:
Scott D. Seiwert, Karl Kossen, John B. Nicholas, Jyanwei Liu, Caralee Schaefer, Brad O. Buckman, Lea Huang, Donald Ruhrmund, Sharlene Lim, Lisa Hooi, Leonid Beigelman, Lin Pan, Vladimir Serebryany, Sarah K. Stevens, Srikonda Sastry, Shawn Misialek, Sophia Yap, Ravi Rajagopalan, Natalia Aleskovski
Publikováno v:
Antimicrobial Agents and Chemotherapy. 61
The current paradigm for the treatment of chronic hepatitis C virus (HCV) infection involves combinations of agents that act directly on steps of the HCV life cycle. Here we report the preclinical characteristics of ITMN-8187, a nonmacrocyclic inhibi
Autor:
Nicholas A. Kartsonis, Johan Maertens, Oliver A. Cornely, Werner J. Heinz, Andrew J. Ullmann, Hetty Waskin, Michael N. Robertson, Hernando Patino, Maria Caceres, Gopal Krishna
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:3610-3617
This was a phase 1B, dose-ranging, multicenter, pharmacokinetics, and safety study of cyclodextrin-based posaconazole intravenous (i.v.) solution administered through a central line to subjects at high risk for invasive fungal disease (part 1 of a 2-
Autor:
Brian P. Kearney, Srinivasan Ramanathan, Gerald Friedland, P. Winkle, R. Douglas Bruce, Xiao-Yong Wei, Martin S. Rhee, Joseph M. Custodio
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:6154-6157
Interactions between HIV and opioid dependence therapies are known to occur. We sought to determine if such interactions occurred between methadone and elvitegravir boosted with cobicistat (EVG/COBI). We performed a within-subject open-label pharmaco
Publikováno v:
Antimicrobial Agents and Chemotherapy. 31:815-817
The objective of this study was to quantitate cefotaxime and its active metabolite, desacetyl cefotaxime, in the distal airways and to compare these levels to concentrations in plasma. Respiratory secretions were obtained from the subsegmental level
Autor:
Alan Forrest, Rachel L. Soon, Anima Poudyal, Phillip J. Bergen, Jovan Jacob, Brian T. Tsuji, Jürgen B. Bulitta, Zakuan Zainy Deris, David L. Paterson, Heidi H. Yu, Jian Li, Roger L. Nation, Kathryn Erin Davis, Tony Velkov, Caron K. Ku
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:5103-5112
Multidrug-resistant (MDR) Klebsiella pneumoniae may require combination therapy. We systematically investigated bacterial killing with colistin and doripenem mono- and combination therapy against MDR K. pneumoniae and emergence of colistin resistance
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:2062-2066
This study characterized the pharmacokinetic/pharmacodynamic profiles of the Food and Drug Administration (FDA)-approved telavancin renal dose adjustment schemes. A previously published two-compartment open model with first-order elimination and a co
Autor:
John Tjia, Enmoore Lin, Akil Jackson, Marta Boffito, Andrew Hill, Marco Siccardi, Saye Khoo, Rebekah Puls, Victoria Watson, Alieu Amara, Paul Fahey, Laura Else, David Back, Sean Emery
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:1427-1433
There is interest in evaluating the efficacy of lower doses of certain antiretrovirals for clinical care. We determined here the bioequivalence of plasma lamivudine (3TC) and intracellular 3TC-triphosphate (3TC-TP) concentrations after the administra