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pro vyhledávání: '"11"'
Autor:
Peter M. Keller, Marcel Yotebieng, Chloé Loiseau, Erik C. Böttger, Kathrin Zürcher, Robert J. Wilkinson, Sonia Borrell, Matthias Egger, Miriam Reinhard, Jimena Collantes, Anchalee Avihingsanon, Peter Sander, Lukas Fenner, Martina L. Reichmuth, Sebastien Gagneux, Rico Hömke
Publikováno v:
Antimicrobial Agents and Chemotherapy
Reichmuth, Martina L.; Hömke, Rico; Zürcher, Kathrin; Sander, Peter; Avihingsanon, Anchalee; Collantes, Jimena; Loiseau, Chloé; Borrell, Sonia; Reinhard, Miriam; Wilkinson, Robert J; Yotebieng, Marcel; Fenner, Lukas; Böttger, Erik C; Gagneux, Sebastien; Egger, Matthias; Keller, Peter Michael (2020). Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-naïve Patients. Antimicrobial agents and chemotherapy, 64(11), e00513-20. American Society for Microbiology 10.1128/AAC.00513-20
Reichmuth, Martina L.; Hömke, Rico; Zürcher, Kathrin; Sander, Peter; Avihingsanon, Anchalee; Collantes, Jimena; Loiseau, Chloé; Borrell, Sonia; Reinhard, Miriam; Wilkinson, Robert J; Yotebieng, Marcel; Fenner, Lukas; Böttger, Erik C; Gagneux, Sebastien; Egger, Matthias; Keller, Peter Michael (2020). Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-naïve Patients. Antimicrobial agents and chemotherapy, 64(11), e00513-20. American Society for Microbiology 10.1128/AAC.00513-20
Mutations in the genes of the F420 signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia,
Autor:
Vegard Eldholm, Abigail L. Manson, Alexander Pym, Kashmeel Maharaj, Lynne de Welzen, Ashlee M. Earl
Publikováno v:
Antimicrobial Agents and Chemotherapy
Genetics-based drug susceptibility testing has improved the diagnosis of drug-resistant tuberculosis but is limited by our lack of knowledge of all resistance mechanisms. Next-generation sequencing has assisted in identifying the principal genetic me
Autor:
David C. Samuels, Fernanda Maruri, Amondrea Blackman, Timothy R. Sterling, Brandon Eilertson, Miguel Herrera
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:3270-3275
Heteroresistance is the coexistence of populations with differing nucleotides at a drug resistance locus within a sample of organisms. Although Sanger sequencing is the gold standard for sequencing, it may be less sensitive than deep sequencing for d
Publikováno v:
Antimicrobial agents and chemotherapy. 39(11)
Resistance to isoniazid in Mycobacterium tuberculosis has been associated with mutations in genes encoding the mycobacterial catalase-peroxidase (katG) and the InhA protein (inhA). Among the 26 isoniazid-resistant clinical isolates evaluated in this