Zobrazeno 1 - 10
of 27
pro vyhledávání: '"11"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:6158-6164
This open-label, fixed-sequence, phase 1 study evaluated the pharmacokinetic interaction between maraviroc (MVC) and ritonavir-boosted fosamprenavir (FPV/r) in healthy subjects. In period 1, subjects received 300 mg of MVC twice daily (BID; cohort 1)
Autor:
Susan L. Ford, Shuguang Chen, David A. Margolis, William Spreen, Elizabeth Gould, Herta Crauwels, Stephen C. Piscitelli
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:5472-5477
Dolutegravir (DTG) and GSK1265744 are HIV integrase inhibitors (INIs) in clinical development. The oral formulation of rilpivirine (RPV), a nonnucleoside reverse transcriptase inhibitor (NNRTI), has been approved for treatment-naive HIV infection. Lo
Autor:
Phillip Hay, Sherene S. Min, Yu Lou, Marta Boffito, Graeme Moyle, Ivy Song, Chris Higgs, Elena M. Guerini, Carl Fletcher, Geoffrey J. Yuen
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:1532-1538
Abacavir (ABC) is administered either at 600 mg once daily (ABC 600 mg QD) or 300 mg twice daily (ABC 300 mg BID) in anti-human immunodeficiency virus (anti-HIV) combination therapy. Although ABC plasma pharmacokinetics following each regimen has bee
Autor:
B Poiesz, E Bonnem, L C Bartos, M L Maliszewski, W D Lawrence, Gene D. Morse, J Santora, Ross G. Hewitt
Publikováno v:
Antimicrobial Agents and Chemotherapy. 37:512-522
Granulocytopenia is a complication of human immunodeficiency virus disease, as well as a toxic manifestation of zidovudine therapy. To evaluate pharmacokinetic and pharmacodynamic relationships, 11 AIDS-AIDS-related complex patients who had developed
Autor:
H Movahhed, S T Forgue, Rashmi H. Barbhaiya, Catherine A. Knupp, Carol Gleason, J Tenney, D J Weidler, Kenneth A. Pittman, R. Russell Martin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 36:552-557
The pharmacokinetics of cefepime in 31 young, healthy volunteers were assessed after the administration of single and multiple 250-, 500-, 1,000-, or 2,000-mg intravenous doses. Each subject received a single dose of cefepime via a 30-min intravenous
Autor:
J A Cook, Richard R. Brown, J J Schentag, David E. Nix, M H Silverman, D J Schelling, R M Stroshane
Publikováno v:
Antimicrobial Agents and Chemotherapy. 34:974-979
The multiple-dose pharmacokinetics and safety of amifloxacin, a new fluoroquinolone antibacterial agent, were evaluated in healthy male volunteers. Amifloxacin was administered orally at 200, 400, or 600 mg every 12 h (q12h) and 400, 600, or 800 mg e
Autor:
Robert M. Grant, Kayla Campbell, Jose R Castillo-Mancilla, Lane R. Bushman, Sybil Hosek, Stacey S Coleman, Samantha MaWhinney, Craig M. Wilson, Edward M. Gardner, David V. Glidden, Sharon M Seifert, Peter L. Anderson, Jia-Hua Zheng, Kevin McAllister, Albert Y. Liu
Publikováno v:
Antimicrobial agents and chemotherapy, vol 60, iss 11
New objective measures of antiretroviral adherence are needed. We determined if emtricitabine triphosphate (FTC-TP) in dried blood spots (DBS) can be used as a marker of recent dosing with tenofovir disoproxil fumarate-emtricitabine (TDF-FTC). The ha
Autor:
John Tjia, Enmoore Lin, Akil Jackson, Marta Boffito, Andrew Hill, Marco Siccardi, Saye Khoo, Rebekah Puls, Victoria Watson, Alieu Amara, Paul Fahey, Laura Else, David Back, Sean Emery
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:1427-1433
There is interest in evaluating the efficacy of lower doses of certain antiretrovirals for clinical care. We determined here the bioequivalence of plasma lamivudine (3TC) and intracellular 3TC-triphosphate (3TC-TP) concentrations after the administra
Autor:
Xavier Sáez-Llorens, Peng Sun, Susan K. Bradshaw, Janaki Raghavan, Mercedes Macias, Nicholas A. Kartsonis, Archana Chatterjee, Padmanabha Maiya, Joseph W. Chow, Marissa Fallon, Sheng Bi, Julie A. Stone, Juan G. Piñeros, Gloria Ruiz, Hasan S. Jafri, Kim M. Strohmaier
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:869-875
Candidainfections represent a major threat in neonatal intensive care units. This is the first prospective study to obtain caspofungin plasma levels and safety data for neonates and very young infants. Patients of n= 6) or subsequent multiple-dose (n
Autor:
Patrick Mamoudy, Nicole Desplaces, Frédérick Durand, Valérie Zeller, Luc Lhotellier, Jean-Marc Ziza, Marie-Dominique Kitzis
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:883-887
Cefazolin has been used for many years to treat bone and joint infections. Because of its time-dependent antimicrobial activity, continuous infusion would potentially be beneficial. We report on the feasibility, safety, and efficacy of prolonged cont