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Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:2463-2468
Recent outbreaks of Clostridium difficile infections (CDI), with increased severity, high relapse rates, and significant mortality, have been related to the emergence of the hypervirulent C. difficile clone toxinotype III/PCR ribotype 027/pulsed-fiel
Publikováno v:
Antimicrobial Agents and Chemotherapy. 47:274-282
Gemifloxacin, a novel quinolone with potent activity against Staphylococcus aureus , was 8- to 16-fold more active against wild-type S. aureus than ciprofloxacin. The two- to fourfold increase in the MIC of gemifloxacin in genetically defined grlBA m
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:3370-3380
We determined the target enzyme interactions of garenoxacin (BMS-284756, T-3811ME), a novel desfluoroquinolone, in Staphylococcus aureus by genetic and biochemical studies. We found garenoxacin to be four- to eightfold more active than ciprofloxacin
Autor:
Anthony Maxwell, Jonathan G. Heddle
Publikováno v:
Antimicrobial Agents and Chemotherapy. 46:1805-1815
Quinolone drugs are a large and widely used class of synthetic antibacterial compounds (10, 11, 19). First-generation (acidic) quinolones include nalidixic acid and oxolinic acid (OXO).Subsequent generations have been modified to increase spectrum an
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:451-452
Aerococcus urinae and Aerococcus sanguinicola are emerging Gram-positive pathogens responsible for urinary tract infections, especially in elderly patients (2). Although they seem to be intrinsically susceptible to fluoroquinolones (3, 8, 10), acquir