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pro vyhledávání: '"59"'
Autor:
A. Fabrice Some, Paul Milligan, François Nosten, Issaka Zongo, Philip J. Rosenthal, Colin J. Sutherland, Jean-Bosco Ouédraogo, Brian Greenwood, Yves Daniel Compaoré, Joel Tarning
Publikováno v:
Antimicrobial agents and chemotherapy, vol 59, iss 8
The WHO recommends that children living in areas of highly seasonal malaria transmission in the Sahel subregion should receive seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine (SPAQ). We evaluated the use of dihy
Autor:
Zachary Herrera, Wesley Wu, Joseph L. DeRisi, Seok H. Cho, Katie Baska, Ellen Yeh, Danny Ebert
Publikováno v:
Antimicrobial agents and chemotherapy, vol 59, iss 1
The apicoplast is an essential plastid organelle found in Plasmodium parasites which contains several clinically validated antimalarial-drug targets. A chemical rescue screen identified MMV-08138 from the “Malaria Box” library of growth-inhibitor
Autor:
Philip J. Rosenthal, Roland A. Cooper, Samuel L. Nsobya, Melissa D. Conrad, Jessica Bloome, Benjamin Kozak, Moses R. Kamya, Diane V. Havlir, Abel Kakuru, Oswald Byaruhanga, Victor Bigira, Jiri Gut, Jennifer Legac, Norbert P. LeClair, Bryan Greenhouse, James Kapisi, Jaffer Okiring, Grant Dorsey, Patrick K Tumwebaze, Andrew Walakira, Christine Nakazibwe
Publikováno v:
Antimicrobial agents and chemotherapy, vol 59, iss 6
Changing treatment practices may be selecting for changes in the drug sensitivity of malaria parasites. We characterized ex vivo drug sensitivity and parasite polymorphisms associated with sensitivity in 459 Plasmodium falciparum samples obtained fro