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Publikováno v:
Antimicrob Agents Chemother
Neisseria gonorrhoeae is the predominant cause of male urethral discharge in South Africa, and escalating prevalence of gonococcal antimicrobial resistance (AMR) is a major health concern both in-country and globally. We analyzed the demographic, beh
Autor:
Melanie T. Cushion, Justin P. Halterman, Kristy Koselny, Thomas F. Patterson, Nathan P. Wiederhold, Annette W. Fothergill, Damian J. Krysan, Chad Rappelye, Louis DiDone, Melanie Wellington, Julianne Green
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:7115-7127
Only one new class of antifungal drugs has been introduced into clinical practice in the last 30 years, and thus the identification of small molecules with novel mechanisms of action is an important goal of current anti-infective research. Here, we d
Autor:
Maseetoh Samaeng, Natnicha Ingviya, Sutep Jaruratanasirikul, Waroonrat Sukarnjanaset, Monchana Nawakitrangsan, Thitima Wattanavijitkul, Wibul Wongpoowarak
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:7236-7244
Sulbactam is being considered as an alternative concomitant medication with other effective antibiotics for the treatment of multidrug-resistant (MDR) Acinetobacter baumannii infections. Pathophysiological changes in critically ill patients with seve
Autor:
Warne Robert L, Heinz E. Moser, Keith Mansfield, Marianne Uteng, Tycho Heimbach, Wang Gang, Weidong Zhong, Lili Xie, Kathryn Rene Bracken, Margaret Weaver, Fumiaki Yokokawa, Zachary Kevin Sweeney, Satya Yendluri, Oliver L. Saunders, Kyoko Uehara, Siew Pheng Lim, Helen Gu, Alexandre Catoire, Martijn Fenaux, Julie Boisclair, Christopher T. Jones, Xiaodong Lin
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:7077-7085
Nucleoside or nucleotide inhibitors are a highly successful class of antivirals due to selectivity, potency, broad coverage, and high barrier to resistance. Nucleosides are the backbone of combination treatments for HIV, hepatitis B virus, and, since
Autor:
Elena Deych, Carey-Ann D. Burnham, William D. Shannon, Meghan A. Wallace, David K. Warren, Stephanie A. Fritz, Patrick G. Hogan
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:7303-7312
Topical antimicrobials are often employed for decolonization and infection prevention and may alter the endogenous microbiota of the skin. The objective of this study was to compare the microbial communities and levels of richness and diversity in co
Autor:
Aradhana Bhargava, Vikram Singh, Manju Bala, Naveen Chandra Joshi, Monika Kakran, Ravi Bhatnagar
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:7518-7521
Antimicrobial susceptibility testing of 258 Neisseria gonorrhoeae isolates by Etest determined that 60.1% were multidrug resistant (MDR), while 5% of the strains had decreased susceptibility to currently recommended extended-spectrum cephalosporins (
Autor:
Sara Cairoli, Rosamaria Crisafulli, Tiziana Corsetti, Maria Paola Ronchetti, Bianca Maria Goffredo, Marco Falcone, Manjunath P. Pai, Andrea Dotta, Cinzia Auriti, Fiammetta Piersigilli
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:7333-7339
High doses of micafungin are advocated in neonates with systemic candidiasis, but limited pharmacokinetic (PK) and safety data are available to support their use. Eighteen preterm neonates and infants with systemic candidiasis, three of whom had meni
Autor:
Marcos Olivo, Rosie Bocanegra, Thomas F. Patterson, David Kadosh, Nathan P. Wiederhold, Laura K. Najvar, William R. Kirkpatrick
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:6703-6708
Candida albicans , normally found as a commensal in the gut, is a major human fungal pathogen responsible for both mucosal and systemic infections in a wide variety of immunocompromised individuals, including cancer patients and organ transplant reci
Autor:
Siôn W. Jones, Ivan Kostov, Allen Wolstenholm, Stephan Duparc, Khadeeja Mohamed, Gavin C. K. W. Koh, Maxine A. Taylor, Azra Hussaini, Samia Bouhired, Navin Goyal, Justin A. Green
Publikováno v:
Antimicrobial Agents and Chemotherapy
Tafenoquine is in development as a single-dose treatment for relapse prevention in individuals with Plasmodium vivax malaria. Tafenoquine must be coadministered with a blood schizonticide, either chloroquine or artemisinin-based combination therapy (
Autor:
Mingyu Chen, Yuancheng Chen, Jufang Wu, Yuyi Zhang, Jing Zhang, Xiaojie Wu, Cheng Lu, Jicheng Yu, Ping Zhong
Publikováno v:
Antimicrobial Agents and Chemotherapy
Meropenem is used to manage postneurosurgical meningitis, but its population pharmacokinetics (PPK) in plasma and cerebrospinal fluid (CSF) in this patient group are not well-known. Our aims were to (i) characterize meropenem PPK in plasma and CSF an