Zobrazeno 91 - 100
of 204
pro vyhledávání: ''
Autor:
Hao Luo, Ryo Yazaki, Takashi Ohshima, Shuhei Ishikura, Senji Shirasawa, Kensuke Nishi, Naoyuki Morishige, Toshiyuki Tsunoda, Anthony Swain
Publikováno v:
Anticancer Research. 38:4247-4256
Background/aim During screening for compounds that selectively suppress growth of human colorectal cancer (CRC) spheroids with mutant (mt) KRAS, the uridine analogue, 5-bromouridine (BrUrd) was identified and its derivatives were explored. Materials
Autor:
Takafumi Mochizuki, Katsuhiro Hayashi, Kentaro Igarashi, Takashi Higuchi, Toshiharu Shirai, Hiroko Ikeda, Norio Yamamoto, Akihiko Takeuchi, Hisaki Aiba, Hiroyuki Tsuchiya, Kensaku Abe, Hiroyuki Inatani, Yuta Taniguchi, Shinji Miwa
Publikováno v:
Anticancer Research. 38:4065-4072
BACKGROUND/AIM Positron emission tomography (PET) using 18fluorine-labelled fluorodeoxyglucose (FDG), is the most widely applied molecular imaging technique in oncology. The present study assessed the efficacy and limitations of FDG-PET by comparing
Publikováno v:
Anticancer Research. 38:3951-3960
Background/aim Melatonin, an endogenously secreted indoleamine hormone that is produced in the pineal gland, is known to possess antitumor effect via various mechanisms including induction of apoptosis and pro-oxidant effects in various cancer cells,
Autor:
Saskia Krohn, Lisa-Madeleine Sklarz, Christoph Wittke, Hugo Murua Escobar, Hartmut Glaeser, Christina Große-Thie, Christian Junghanss
Publikováno v:
Anticancer Research. 38:3961-3966
Since the introduction of tyrosine kinase inhibitors (TKI), the prospects for patients with chronic myeloid leukemia (CML) have improved significantly. Herein we present the case of a patient with CML who experienced blast crisis and development of a
Publikováno v:
Anticancer Research. 38:3967-3975
BACKGROUND/AIM Natural products extracted from plants can be potent for developing pharmaceutical products. Hispidin, a polyphenolic compound mainly derived from the medicinal mushroom Phellinus linteus, has been shown to have a therapeutic potential
Autor:
Kenjiro Kawakami, Mana Ikeda, Masaaki Nomura, Tatsuo Takahashi, Eiko Sato, Shinjiro Kobayashi, Sinya Ohta
Publikováno v:
Anticancer research. 39(12)
Background/aim Human lung adenocarcinoma PC14 cells without mutations in the epidermal growth factor receptor (EGFR) are less sensitive to gefitinib than PC9 cells with EGFR mutations. We report the involvement of tetrandrine in autophagy flux as a m
Autor:
Tsunehiro Nishi, Takao Kato, Masashi Takeuchi, Munechika Tsuji, Sotaro Akatsuka, Atsushi Fukuuchi, Daisuke Ota
Publikováno v:
Anticancer research. 39(12)
Background/aim The objective of this phase I study was to determine the maximum-tolerated dose (MTD) and recommended dose (RD) of combination therapy with weekly nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and cyclophosphamide (CPA) in met
Autor:
Kazuhiko Yamada, Tomoaki Hoshino, Yoshiko Naito, Masao Ichiki, Koichi Azuma, Norikazu Matsuo, Takaaki Tokito, Hidenobu Ishii, Hiroaki Takeoka
Publikováno v:
Anticancer Research. 38:3779-3784
Background/aim The combination of platinum-doublet chemotherapy with bevacizumab has been established as a first-line treatment option in non-elderly patients with non-squamous (non-sq) non-small cell lung cancer (NSCLC). However, the safety and effi
Autor:
Jacopo Giuliani, Andrea Bonetti
Publikováno v:
Anticancer Research. 39:3967-3969
Background/aim The aim of this report was to evaluate the onset of grade≥3 neutropenia during the first-cycle in patients with metastatic colorectal cancer (mCRC) treated with trifluridine/tipiracil and its relationship with clinical parameters of
Publikováno v:
Anticancer Research. 37:1647-1653
BACKGROUND This study tested the effect of the soy isoflavones genistein and ME-143, and two chemotherapeutic agents, 5-fluorouracil (5FU) and oxaliplatin, on WNT signaling. MATERIALS AND METHODS Colon cancer cell lines RKO (hereditary nonpolyposis c