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Autor:
Robin Temmerman, Mathias Devreese, Mia Vanrobaeys, An Garmyn, Gunther Antonissen, Gerty Vanantwerpen, Freddy Haesebrouck
Publikováno v:
Antibiotics, Vol 9, Iss 800, p 800 (2020)
Antibiotics
Volume 9
Issue 11
ANTIBIOTICS-BASEL
Antibiotics
Volume 9
Issue 11
ANTIBIOTICS-BASEL
Fluoroquinolones are frequently used antimicrobials for the treatment of avian pathogenic Escherichia coli (APEC) infections. However, rapid development and selection of resistance to this class of antimicrobial drugs is a significant problem. The ai
Autor:
Frank Schweizer, Temilolu Idowu
Publikováno v:
Antibiotics
Antibiotics, Vol 6, Iss 4, p 26 (2017)
Antibiotics, Vol 6, Iss 4, p 26 (2017)
Fluoroquinolones are synthetic antibacterial agents that stabilize the ternary complex of prokaryotic topoisomerase II enzymes (gyrase and Topo IV), leading to extensive DNA fragmentation and bacteria death. Despite the similar structural folds withi