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Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:2048-2062
Apoptosis is a programmed cell death that occurs due to the production of several catabolic enzymes. During this process, several morphological and biochemical changes occur in mitochondria, the main organelle in the cell that participates in apoptos
Autor:
Gholamreza Dehghan, Elham Kamalkazemi, Nader Sheibani, Fereydoon Abedi-Gaballu, Ali Mohammadi, Tala Farid Mohammad Hosseini, Behzad Mansoori, Behzad Baradaran
Publikováno v:
Kazemi, E K, Abedi-Gaballu, F, Mohammad Hosseini, T F, Mohammadi, A, Mansoori, B, Dehghan, G, Baradaran, B & Sheibani, N 2022, ' Glimpse into the Cellular Internalization and Intracellular Trafficking of Lipid-Based Nanoparticles in Cancer Cells ', Anti-Cancer Agents in Medicinal Chemistry, vol. 22, no. 10, pp. 1897-1912 . https://doi.org/10.2174/1871520621666210906101421
Lipid-based nanoparticles as drug delivery carriers have been mainly used for delivery of anti-cancer therapeutic agents. Lipid-based nanoparticles, due to their smaller particle size and similarity to cell membranes, are readily internalized into ca
Autor:
Sukhes Mukherjee, Suman Kumar Ray
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:1257-1271
Tissues are progressively molded by bidirectional correspondence between denizen cells and extracellular matrix (ECM) via cell-matrix connections along with ECM remodeling. The composition and association of ECM are spatiotemporally directed to contr
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:943-950
Background: Tyrosine Kinase Inhibitors (TKIs) can be used to inhibit cancer cell proliferation by targeting the vascular endothelial growth factor receptor (VEGFR) family. SAR131675 is a highly selective receptor tyrosine kinase inhibitor to VEGFR3 t
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 21:640-648
Background: T-LAK cell-Originated Protein Kinase (TOPK) belongs to the serine/threonine protein kinase family. It is highly expressed in RPMI7951 melanoma cells. Scutellarin (SCU) is an active ingredient extracted from Erigeron breviscapus (Vant.) Ha
Autor:
Shabnoor Iqbal, Muhammad Zafar, Gaber El-Saber Batiha, Azhar Rasul, Sobia Tabassum, Haji Muhammad, Muhammad Ajmal Shah, Celia Vargas-De-La-Cruz, Malik Saadullah, Sahab Uddin, Shujat Ali
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 22:40-52
Radiations are an efficient treatment modality in cancer therapy. Besides the treatment effects of radiations, the ionizing radiations interact with biological systems and generate reactive oxygen species that interfere with the normal cellular proce
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 20:834-844
Background: microRNAs are known to regulate various protein-coding gene expression posttranscriptionally. Fatty acids are cell membrane constituents and are also known to influence the biological activities of the cells like signal transduction, grow
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 20:571-579
Background: The Enhancer of Zeste Homolog 2 (EZH2) is a subunit of the polycomb repressive complex 2 that silences the gene transcription via H3K27me3. Previous studies have shown that EZH2 has an important role in the induction of the resistance aga
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 19:2177-2196
Autophagy, an intricate response to nutrient deprivation, pathogen infection, Endoplasmic Reticulum (ER)-stress and drugs, is crucial for the homeostatic maintenance in living cells. This highly regulated, multistep process has been involved in sever
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 18:1656-1673
Background: The 26S proteasome is a proteolytic complex of multimeric protease, which operates at the executive end of the Ubiquitin-Proteasome System (UPS) and degrades the polyubiquitylated proteins. Methods: After a brief introduction of 26S prote