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Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 20:834-844
Background: microRNAs are known to regulate various protein-coding gene expression posttranscriptionally. Fatty acids are cell membrane constituents and are also known to influence the biological activities of the cells like signal transduction, grow
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 19:2177-2196
Autophagy, an intricate response to nutrient deprivation, pathogen infection, Endoplasmic Reticulum (ER)-stress and drugs, is crucial for the homeostatic maintenance in living cells. This highly regulated, multistep process has been involved in sever
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 18:1582-1588
Background: The Bursa of Fabricius (BF) is acknowledged as the central humoral immune organ unique to birds. Bursal Hexapeptide (BHP, AGCCNG) is a recently reported bursal-derived bioactive peptide. However, there are few reports of the molecular bas
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 16:75-88
The therapeutic potential of targeting p21-Activated Kinases (PAK1 - 6) for the treatment of cancer has recently gained traction in the biotech industry. Many pharmaceutically-viable ATP competitive inhibitors have been through different stages of pr
Autor:
Dingqun Bai, Tinghe Yu, Yuan Jiang, Jiang Zhu, Lehua Yu, Si Tian, Min Yong, Kai-Ting Li, Qing Chen, Yu-Han Kong, Li Pan, Li Zhang
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 17
Emerging evidence indicates that the transcription factor nuclear factor-E2-related factor 2 (Nrf2) plays an essential role in cellular defense against oxidative stress; its activation has been related to cytoprotection.Here, we investigated the role
Autor:
Deokho Jung, Youngeun Kwon, Junghyun Jung, Chang Seo Park, Hyunjin Jeon, Euiyeon Lee, Wonhee Jang, Chang Soo Mok
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 17
Background Cell migration is an essential process for survival and differentiation of mammalian cells. Numerous diseases are induced or influenced by inappropriate regulation of cell migration, which plays a key role in cancer cell metastasis. In fac
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 14:559-577
Many types of cancer, for example glioblastoma, show resistance against current anti-cancer treatments. One reason is that they are not capable to effectively activate their intracellular cell death pathways. Novel treatments designed to overcome the
Autor:
Duo Li, Qiong Liu, Chen-Wei Xu, Lin Tang, Shiyong Chen, Ying-Zhuo Shen, Lin Luo, Xiaohong Zhang
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 13:1575-1581
The present investigation was undertaken to gain insight into the molecular mechanism by which myricetin induces apoptosis in human hepatocarcinoma HepG2 cells. Myricetin caused the disruption of mitochondrial membrane potential in a dose-dependent m
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 13:1565-1574
Cinnamaldehyde (CIN) has been shown to exert chemopreventive activity against several types of human cancer cells. We previously reported that CIN induced apoptosis of human hepatoma PLC/PRF/5 cells and this effect was associated with activation of t
Autor:
Asif Khurshid Qazi, Abid Hamid, Rabiya Majeed, Shakir Ali, Mohmmad Afzal Zargar, Shashank K. Singh, Ajit Kumar Saxena, Mudassier Ahmad, Yasrib Qurishi, Rauf Ahmad Najar, Javeed Ahmad Bhat, Aashiq Hussain
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 13:1552-1564
Cancer is a diverse class of diseases which differ widely in their cause and biology. The aberrant behavior of cancer reflects up regulation of certain oncogenic signaling pathways that promote proliferation, inhibit apoptosis, and enable the cancer