Zobrazeno 1 - 6
of 6
pro vyhledávání: ''
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 21:640-648
Background: T-LAK cell-Originated Protein Kinase (TOPK) belongs to the serine/threonine protein kinase family. It is highly expressed in RPMI7951 melanoma cells. Scutellarin (SCU) is an active ingredient extracted from Erigeron breviscapus (Vant.) Ha
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 20:571-579
Background: The Enhancer of Zeste Homolog 2 (EZH2) is a subunit of the polycomb repressive complex 2 that silences the gene transcription via H3K27me3. Previous studies have shown that EZH2 has an important role in the induction of the resistance aga
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 18:985-992
This systematic review aims to elucidate the role of melatonin (N-acetyl-5-metoxy-tryptamine) (MLT) in the prevention and treatment of cancer. MLT is a pineal gland secretory product, an evolutionarily highly conserved molecule; it is also an antioxi
Autor:
Hiroyuki Shibata, Chikashi Ishioka, Yoshiharu Iwabuchi, Masamitsu Tanaka, Kazunori Otsuka, Keigo Komine, Yuki Yoshino, Sei Kuriyama, Aki Kohyama, Masahiro Inoue, Shunsuke Sugiyama, Hiroyuki Yamakoshi
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 16:633-647
Background: The inhibition of angiogenesis is a theoretically ideal chemotherapy for cancer, but there remains room for improvement. Most inhibitors of angiogenesis approved to date target vascular endothelial growth factors (VEGFs); however, VEGFs a
Autor:
Yang Wang, Keke Huo, Chengyuan Zhou, Wei Yan, Qiaoming Zhi, Di Zhang, Lei Zhang, Qun Wu, Qin Ye, Pu Li
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 16:440-446
The cell cycle is regulated via important biological mechanisms. Controlled expression of cell cycle regulatory proteins is crucial to maintain cell cycle progression. However, unbalanced protein expression leads to many diseases, such as cancer. Pre
Autor:
Dingqun Bai, Tinghe Yu, Yuan Jiang, Jiang Zhu, Lehua Yu, Si Tian, Min Yong, Kai-Ting Li, Qing Chen, Yu-Han Kong, Li Pan, Li Zhang
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 17
Emerging evidence indicates that the transcription factor nuclear factor-E2-related factor 2 (Nrf2) plays an essential role in cellular defense against oxidative stress; its activation has been related to cytoprotection.Here, we investigated the role