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Autor:
Masao Hashimoto, Rafi Ahmed, Suresh S. Ramalingam, Se Jin Im, Haydn T. Kissick, Koichi Araki, Alice O. Kamphorst, Rathi N. Pillai
Publikováno v:
Annual review of medicine. 69
Antigen-specific CD8 T cells are central to the control of chronic infections and cancer, but persistent antigen stimulation results in T cell exhaustion. Exhausted CD8 T cells have decreased effector function and proliferative capacity, partly cause