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Autor:
Michael Bonelli, Stephan Blüml, Philipp Hofer, Leonhard X. Heinz, Stefan Winkler, Daniela Sieghart, Josef S Smolen, Marianne Graninger, Daniel Aletaha, Karin Stiasny, Helmuth Haslacher, Helga Radner, Selma Tobudic, Maximilian Koblischke, Renate Thalhammer, Thomas Perkmann, Daniel Mrak, Judith H. Aberle
Publikováno v:
Annals of the Rheumatic Diseases
ObjectivesEvidence suggests that B cell-depleting therapy with rituximab (RTX) affects humoral immune response after vaccination. It remains unclear whether RTX-treated patients can develop a humoral and T-cell-mediated immune response against SARS-C
Autor:
María Laura Acosta Felquer, Luciano LoGiudice, Enrique R. Soriano, María Laura Galimberti, Luis Daniel Mazzuoccolo, Javier Rosa
Publikováno v:
Annals of the Rheumatic Diseases. 81:74-79
ObjectivesTo compare the incidence of psoriatic arthritis (PsA) in patients with psoriasis (PsO) according to different treatments for their skin: topics/no treatment, conventional disease-modifying antirheumatic drugs (DMARDs) (cDMARDs) or biologica
Autor:
Antonio Manzo, Silvia Balduzzi, Eleonora Mauric, Laura Bogliolo, Fausto Baldanti, Terenzj Luvaro, Bernardo D’onofrio, Daniele Lilleri, Serena Bugatti, Maria Immacolata Greco, Ludovico De Stefano, Michele di Lernia, Irene Cassaniti, Iolanda Mazzucchelli, Carlomaurizio Montecucco
Publikováno v:
Annals of the Rheumatic Diseases. 80:1635-1638
Strategies aimed at expediting immunisation campaigns against COVID-19 include providing single vaccine doses to individuals with previous exposure to SARS-CoV-2 and delaying second doses. While such approaches are effective at the population level,
Autor:
Nirupam Purkayastha, Myles Lewis, Katriona Goldmann, W.S. Tan, Alessandra Nerviani, Stephen Kelly, Marie-Astrid Boutet, Tamás Lajtos, Costantino Pitzalis, Rebecca Hands
Publikováno v:
Annals of the Rheumatic Diseases
ObjectivesTo determine the relationship between synovial versus skin transcriptional/histological profiles in patients with active psoriatic arthritis (PsA) and explore mechanistic links between diseased tissue pathology and clinical outcomes.Methods
Autor:
Hendrik Schulze-Koops, Andrea Shapiro, Dimitrios A. Pappas, Kevin L. Winthrop, Harry Shi, David Gold, D. Henrohn, Gustavo Citera, Alina Onofrei, Carol A. Connell
Publikováno v:
Annals of the Rheumatic Diseases
A randomised, open-label, blinded endpoint post-authorisation safety study (Study A3921133; NCT02092467; database not locked and subject to change) evaluated the safety of tofacitinib 5 mg and 10 mg twice daily (BID) versus tumour necrosis factor inh
Autor:
Sharon Nevo, Gabi Shefer, Devy Zisman, Ira Litinsky, Adi Broyde, Jonathan Wollman, Michael Zisapel, David Levartovsky, Amir Haddad, Victoria Furer, Hila Nochomovitz, Ori Elkayam, Joy Feld, Orly Sharon, Tal Gazzit, Katya Meridor, Dana Rosenberg, Daphna Paran, Fadi Kharouf, Hagit Peleg, Nizar Higazi, Adi Silberman, Ari Polachek, Tali Eviatar, Ofir Elalouf, Muna Elias, Sara Pel, Ilana Kaufman, Roni Meidan
Publikováno v:
Annals of the rheumatic diseases. 80(10)
IntroductionVaccination represents a cornerstone in mastering the COVID-19 pandemic. Data on immunogenicity and safety of messenger RNA (mRNA) vaccines in patients with autoimmune inflammatory rheumatic diseases (AIIRD) are limited.MethodsA multicent
Publikováno v:
Annals of the rheumatic diseases. 80(10)
There is a paucity of data on the effect of antirheumatic drugs on serological responses to COVID-19 vaccines. Anti-CD20 therapies deplete B-cells, with reconstitution often not beginning for 6–9 months after infusion, resulting in diminished humor
Publikováno v:
Annals of the rheumatic diseases. 80(11)
The advent of biological and targeted synthetic disease-modifying anti-rheumatic drugs (b/tsDMARDs) has improved the management of rheumatoid arthritis (RA) dramatically. However, there are patients who have not been controlled adequately, and EULAR
Autor:
Connie Chen, Lisy Wang, Ernest Choy, Koshika Soma, Pinaki Biswas, Ann Wouters, Hernan Valdez, William F. C. Rigby, Elie Needle, Kevin L. Winthrop
Publikováno v:
Annals of the Rheumatic Diseases
Herpes zoster (HZ) incidence is higher in patients with rheumatoid arthritis (RA) compared with the general population,1 and it may be further increased with disease-modifying antirheumatic drugs (DMARDs).2 Tofacitinib is an oral Janus kinase inhibit
Autor:
Jialin Teng, Junna Ye, Qiongyi Hu, Liyan Wan, Yutong Su, Honglei Liu, Mengyan Wang, Huihui Chi, Hui Shi, Yue Sun, Zhihong Wang, Zhuochao Zhou, Jinchao Jia, Chengde Yang, Tingting Liu, Fan Wang, Xiaobing Cheng
Publikováno v:
Annals of the Rheumatic Diseases
Adult-onset Still’s disease (AOSD) is an autoinflammatory disease characterised by spiking fever, rash, polyarthralgia, sore throat and even life-threatening complications, such as macrophage activation syndrome and fulminant hepatitis. Excessive a