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Autor:
Yingsheng Xu, Cuishuan Wu, Chunli Song, Junxiong Zhu, Chenggui Zhang, Jialin Jia, Qiang Zhang, Huijie Leng, Hong Wang
Publikováno v:
Annals of the New York Academy of Sciences. 1487:31-42
Simvastatin is a translational drug that may be used to induce local bone formation. In this study, simvastatin microcrystals were made by a wet media milling method, and then we verified the osteogenic effect of the microcrystals in rat ovariectomy
Autor:
Matthew S. Halquist, Robert J. DeLorenzo, Robert E. Blair, Leon Kosmider, Laxmikant S. Deshpande
Publikováno v:
Ann N Y Acad Sci
Organophosphorus (OP) compounds are chemical threat agents and are irreversible inhibitors of the enzyme acetylcholinesterase that lead to a hypercholinergic response that could include status epilepticus (SE). SE particularly targets the heart and t
Autor:
Eduardo A. González, Danielle J Harvey, Ashish Dhir, Donald A. Bruun, Daniel J. Tancredi, Pamela J. Lein, Jonas J. Calsbeek, Naomi Saito, Michelle Guignet, Joan Vu, Yi Hua Tsai, Michael A. Rogawski
Publikováno v:
Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences, vol 1480, iss 1
Annals of the New York Academy of Sciences, vol 1480, iss 1
Combinations of midazolam, allopregnanolone, and perampanel were assessed for antiseizure activity in a rat diisopropylfluorophosphate (DFP) status epilepticus model. Animals receiving DFP followed by atropine and pralidoxime exhibited continuous hig
Autor:
Leslie A. Bloomquist, William Sosna, Eric Peters, Livia A. Veress, Carl W. White, Richard S. Tuttle, Poojya Anantharam, Claire R. Croutch, Heidi J. Nick, Jacqueline S. Rioux, Preston E. Bratcher
Publikováno v:
Ann N Y Acad Sci
Methyl isocyanate (MIC, “Bhopal agent”) is a highly reactive, toxic industrial chemical. Inhalation of high levels (500–1000 ppm) of MIC vapor are almost uniformly fatal. No therapeutic interventions other than supportive care have been describ
Publikováno v:
Annals of the New York Academy of Sciences. 844(1)
Taking into account that methamphetamine (MA) is a popular recreational drug among young adult women, i.e., in gestational age, the present model aims to assess the effects of its exposure during development. In this experimental model, MA effects ar
Publikováno v:
Annals of the New York Academy of Sciences. 1374(1)
Current oxime reactivators for organophosphate-inhibited cholinesterase (ChE) do not effectively cross the blood–brain barrier and therefore cannot restore brain ChE activity in vivo. Our laboratories have studied highly relevant sarin and VX surro
Publikováno v:
Annals of the New York Academy of Sciences. 1170:347-364
Cumulative evidence in rats suggests that the pontine parabrachial nuclei (PBN) are necessary for assigning hedonic value to taste stimuli. In a series of studies, our laboratory has investigated the parabrachial coding of sapid sucrose in normal and
Publikováno v:
Annals of the New York Academy of Sciences. 1160:250-255
The hypothalamus plays a key role in the regulation of energy homeostasis and endocrine function. Relaxin-3 is a hypothalamic neuropeptide that belongs to the insulin superfamily of peptides. It is expressed in the nucleus incertus of the brainstem,
Autor:
Robert S. Freeman, Harley I. Kornblum, Ksenia Karpisheva, Ambreena Siddiq, Ronald P. Hart, Hsin Hwa Lee, Michael S. Beattie, Sashwati Roy, Thomas S. Carmichael, Irina G. Gazaryan, Stephen J. McConoughey, Martin Grumet, Brett Langley, Ahmet Hoke, Rajiv R. Ratan, Gregg L. Semenza, Chandan K. Sen, Cameron Rink, Dongming Sun, N. A. Smirnova, Leila Aminova, Daniel H. Geschwind, Giovanni Coppola
Publikováno v:
Annals of the New York Academy of Sciences. 1147:383-394
A major challenge for neurological therapeutics is the development of small molecule drugs that can activate a panoply of downstream pathways without toxicity. Over the past decade our group has shown that a family of enzymes that regulate posttransc
Publikováno v:
Annals of the New York Academy of Sciences. 1148:165-173
Exposure to some predominantly emotional (electric shock) and systemic (interleukin-1beta) stressors has been found to induce long-term sensitization of the hypothalamic-pituitary-adrenal (HPA) responsiveness to further superimposed stressors. Since