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Prenatal Cocaine Exposure Affects Postnatal Dopaminergic Systems in Various Regions of the Rat Brain
Publikováno v:
Annals of the New York Academy of Sciences. 844(1)
Pregnant female Sprague-Dawley rats were injected once daily with either 40 mg/kg cocaine hydrochloride or 0.9% saline from gestation day (GD)12 to GD 21. On postnatal day (PND)30, male offspring were sacrificed and fresh tissue from the striatum (ST
Publikováno v:
Annals of the New York Academy of Sciences. 844(1)
Male Sprague-Dawley rats were administered 25 mg/kg, intraperitoneally (i.p.) cocaine-HCI twice daily for 14 consecutive days (total of 50 mg/kg), while control animals received an equivalent volume of 0.9% saline. After three days of withdrawal, the
Autor:
Virginia M. Pickel, Marisela Morales
Publikováno v:
Annals of the New York Academy of Sciences. 1248:71-88
Drugs of abuse increase the release of dopamine from mesocorticolimbic neurons in the ventral tegmental area. Thus, insights into the cytoarchitecture and the synaptic circuitry affecting the activity of dopaminergic neurons in this area are fundamen
Autor:
Pauline Belujon, Anthony A. Grace
Publikováno v:
Annals of the New York Academy of Sciences. 1216:114-121
Stress is one of the major factors in drug abuse, particularly in relapse and drug-seeking behavior. However, the mechanisms underlying the interactions between stress and drug abuse are unclear. For many years, studies have focused on the role of th
Publikováno v:
Annals of the New York Academy of Sciences. 1187:129-139
In an ever-changing environment, animals must learn new behavioral strategies for the successful procurement of food, sex, and other needs. Synaptic plasticity within the mesolimbic system, a key reward circuit, affords an animal the ability to adapt
Autor:
Ivan E. de Araujo
Publikováno v:
Annals of the New York Academy of Sciences. 1170:383-391
Previous studies demonstrate that lesions to the rodent parabrachial nucleus (PBN) disrupt the formation of gustatory-postingestive associations, while preserving gustatory and viscerosensory functions. This suggests that the rodent PBN functions ess
Publikováno v:
Annals of the New York Academy of Sciences. 1170:347-364
Cumulative evidence in rats suggests that the pontine parabrachial nuclei (PBN) are necessary for assigning hedonic value to taste stimuli. In a series of studies, our laboratory has investigated the parabrachial coding of sapid sucrose in normal and
Publikováno v:
Annals of the New York Academy of Sciences. 1141:96-104
Astrocytes are a subpopulation of glial cells that directly affect neuronal function. This review focuses on the potential functional roles of astrocytes in the development of behavioral sensitization and rewarding effects induced by chronic treatmen
Autor:
Alessandra Tiziana Peana, Miriam Melis, Paolo Enrico, Alessandra Lintas, Marco Diana, Donatella Sirca
Publikováno v:
Annals of the New York Academy of Sciences. 1139:307-317
Ethyl alcohol (EtOH), the main psychoactive ingredient of alcoholic drinks, is widely considered responsible for alcohol abuse and alcoholism through its positive motivational properties, which depend, at least partially, on the activation of the mes
Autor:
Richard D. Palmiter
Publikováno v:
Annals of the New York Academy of Sciences. 1129:35-46
Genetically engineered mice that lack tyrosine hydroxylase in all dopaminergic neurons become hypoactive and aphagic, and they starve by 4 weeks of age. However, they can be rescued by daily treatment with l-dopa, which restores activity and feeding