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Publikováno v:
Annals of the New York Academy of Sciences. 1170:347-364
Cumulative evidence in rats suggests that the pontine parabrachial nuclei (PBN) are necessary for assigning hedonic value to taste stimuli. In a series of studies, our laboratory has investigated the parabrachial coding of sapid sucrose in normal and
Autor:
Alessandra Tiziana Peana, Miriam Melis, Paolo Enrico, Alessandra Lintas, Marco Diana, Donatella Sirca
Publikováno v:
Annals of the New York Academy of Sciences. 1139:307-317
Ethyl alcohol (EtOH), the main psychoactive ingredient of alcoholic drinks, is widely considered responsible for alcohol abuse and alcoholism through its positive motivational properties, which depend, at least partially, on the activation of the mes
Persistent and Reversible Morphine Withdrawal-Induced Morphological Changes in the Nucleus Accumbens
Publikováno v:
Annals of the New York Academy of Sciences. 1074:446-457
Morphine withdrawal produces a hypofunction of mesencephalic dopamine (DA) neurons which impinge upon medium spiny neurons (MSN) of the forebrain. After chronic treatment rats were either spontaneously or pharmacologically withdrawn from chronic morp
Autor:
Alois Saria, Gerald Zernig, Leigh V. Panlilio, Katja Sturm, Jose A. Crespo, Charles W. Schindler
Publikováno v:
Annals of the New York Academy of Sciences. 1074:497-504
An individual's drug abuse pattern is determined by a multitude of factors. Among these, simple pharmacological determinants of within-binge drug consumption are sorely underinvestigated. We therefore determined if within-session operant responsing t
Autor:
L. J. Almodóvar-Fábregas, Carlos A. Jiménez-Rivera, J. T. Williams, E. Vázquez, N. Colon, C. A. Mejías-Aponte, R. Vazquez, R. Abreu, M. Mercado, O. Segarra, J. G. Dones
Publikováno v:
Annals of the New York Academy of Sciences. 965:157-171
The repeated use of psychostimulants in humans has been associated with progressive enhancement of anxiety, panic attacks, and eventually paranoid psychosis. The appearance of such behaviors has been termed behavioral sensitization, which forms part
Publikováno v:
Annals of the New York Academy of Sciences. 965:47-54
The nitric oxide (NO)/cGMP pathway triggers key events in synaptic phenomena involved in learning and memory. Using in situ hybridization, the present report demonstrates that NO released by sodium nitroprusside regulates egr-1, c-fos, and junB immed
Autor:
Javier Fernández-Ruiz, Joana Gomes-Da-Silva, Teresa Summavielle, M. Amélia Tavares, Rosario de Miguel
Publikováno v:
Annals of the New York Academy of Sciences. 1025:602-611
Neonatal exposure to moderate doses of methamphetamine during the first month of life in the rat affects tyrosine hydroxylase gene expression in the substantia nigra and nigrostriatal tyrosine hydroxylase activity. The main goal of this work was to e
Autor:
Cheryl L. Kirstein, Rex M. Philpot
Publikováno v:
Annals of the New York Academy of Sciences. 1021:422-426
Recent research indicates that alcohol use/abuse is often initiated during the adolescent period and that brain reinforcement pathways (e.g., the mesolimbic dopamine [DA] pathway) are undergoing developmental transition. Our research focuses on the e
Publikováno v:
Annals of the New York Academy of Sciences. 1021:410-417
Many drug-dependent adults began using drugs during adolescence. In fact, adolescent drug users are more likely to become drug-dependent adults than those abstaining from drug use until after the age of 18. Because of this, recent research has begun
Publikováno v:
Annals of the New York Academy of Sciences. 914:354-368
Ibogaine (IBO) is a plant-derived alkaloid that is being evaluated as a possible medication for substance use disorders. When administered peripherally to monkeys and humans, IBO is rapidly converted to an o-demethylated metabolite, 12-hydroxyibogami