Zobrazeno 1 - 10
of 28
pro vyhledávání: ''
Persistent and Reversible Morphine Withdrawal-Induced Morphological Changes in the Nucleus Accumbens
Publikováno v:
Annals of the New York Academy of Sciences. 1074:446-457
Morphine withdrawal produces a hypofunction of mesencephalic dopamine (DA) neurons which impinge upon medium spiny neurons (MSN) of the forebrain. After chronic treatment rats were either spontaneously or pharmacologically withdrawn from chronic morp
Autor:
L. J. Almodóvar-Fábregas, Carlos A. Jiménez-Rivera, J. T. Williams, E. Vázquez, N. Colon, C. A. Mejías-Aponte, R. Vazquez, R. Abreu, M. Mercado, O. Segarra, J. G. Dones
Publikováno v:
Annals of the New York Academy of Sciences. 965:157-171
The repeated use of psychostimulants in humans has been associated with progressive enhancement of anxiety, panic attacks, and eventually paranoid psychosis. The appearance of such behaviors has been termed behavioral sensitization, which forms part
Publikováno v:
Annals of the New York Academy of Sciences. 1021:410-417
Many drug-dependent adults began using drugs during adolescence. In fact, adolescent drug users are more likely to become drug-dependent adults than those abstaining from drug use until after the age of 18. Because of this, recent research has begun
Publikováno v:
Annals of the New York Academy of Sciences. 914:354-368
Ibogaine (IBO) is a plant-derived alkaloid that is being evaluated as a possible medication for substance use disorders. When administered peripherally to monkeys and humans, IBO is rapidly converted to an o-demethylated metabolite, 12-hydroxyibogami
Publikováno v:
Annals of the New York Academy of Sciences. 914:336-353
Administration of triadimefon (TDF) [1-(4-chlorophenoxy)-3,3-dimethyl-1-(1-H-1,2,4-triazol-1-yl)-2-butanone] in rodents incites heightened locomotor and stereotypy response, primarily through potentiation of dopaminergic activity. In the present stud
Autor:
Mario A. Ayestas, John S. Partilla, Richard B. Rothman, Christina M. Dersch, Michael H. Baumann
Publikováno v:
Annals of the New York Academy of Sciences. 914:172-186
Administration of d,l-fenfluramine (FEN), or the more active isomer d-fenfluramine (dFEN), causes long-term depletion of forebrain serotonin (5-HT) in animals. The mechanism underlying FEN-induced 5-HT depletion is not known, but appears to involve 5
Publikováno v:
Annals of the New York Academy of Sciences. 914:316-322
Mesolimbic dopamine neurons in the ventral tegmental area (VTA), which project to the nucleus accumbens and prefrontal cortex, play an important role in the regulation of emotion, rewarding, and cognition. The dopamine neurons in the VTA have also be
Autor:
Junko Suemaru, Kazufumi Akiyama
Publikováno v:
Annals of the New York Academy of Sciences. 914:263-274
Several lines of evidence have implicated Ca2+/calmodulin (CaM)-dependent protein kinase II (CaM-kinase II), a multifunctional protein kinase, in the regulation of signal transduction after chronic administration of psychostimulants. CaM-Kinase II ac
Publikováno v:
Annals of the New York Academy of Sciences. 877:803-806
Publikováno v:
Annals of the New York Academy of Sciences. 877:769-774
Antidepressants alleviate behavioral depression via monoamines, notably serotonin,1,2 but the next step in the mechanism is not established. A possible role of acetylcholine in mood disorders has been widely discussed,3,4 although it is not clear whi