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Autor:
Frank C. Barone, Giora Z. Feuerstein, Juan L. Gu, Robert R. Ruffolo, Paul G. Lysko, Tian L. Yue
Publikováno v:
Annals of the New York Academy of Sciences. 738:230-242
The antioxidant activities of carvedilol have been demonstrated in a wide variety of test systems, including (i) physicochemical (EPR studies), (ii) biochemical (measurement of lipid peroxidation and endogenous antioxidant depletion), (iii) cellular,
Publikováno v:
Annals of the New York Academy of Sciences. 939:179-186
Nefiracetam is a new pyrrolidone nootropic drug that is being developed for clinical use in the treatment of post-stroke vascular-type and Alzheimer's-type dementia. Among a few neuroreceptors that have been identified as potential targets of nootrop
Publikováno v:
Annals of the New York Academy of Sciences. 965:180-192
Sydnocarb [(phenylisopropyl)N-phenylcarbamoylsydnonimine; SYD] was introduced to clinical practice in Russia as a psychostimulant drug used for the treatment of asthenia and apathy, which accompany schizophrenia and manic depression. It has been desc
Publikováno v:
Annals of the New York Academy of Sciences. 1025:69-75
To reveal specific gene expression in methamphetamine (METH) -induced dopamine neurotoxicity, temporal characteristics of METH-induced changes in gene expression in dopaminergic neuronal cells were examined using the cDNA array and the differential d
Publikováno v:
Annals of the New York Academy of Sciences. 962:60-72
To investigate whether nitric oxide (•NO) is neurotoxic or neuroprotective in the brain, we compared the in vivo role of S-nitroso-N-acetylpenicillamine (SNAP) with that of sodium nitroprusside (SNP) on ferrous citrate-induced oxidative stress and
Autor:
Sonia Ordonez, Jean Lud Cadet
Publikováno v:
Annals of the New York Academy of Sciences. 914:82-91
Methamphetamine (METH) has been shown to cause neurotoxic damage both in vitro and in vivo. The mechanisms of action are thought to involve the production of pathophysiologic concentration of free radicals. The present study was undertaken to assess
Publikováno v:
Annals of the New York Academy of Sciences. 914:316-322
Mesolimbic dopamine neurons in the ventral tegmental area (VTA), which project to the nucleus accumbens and prefrontal cortex, play an important role in the regulation of emotion, rewarding, and cognition. The dopamine neurons in the VTA have also be
Publikováno v:
Annals of the New York Academy of Sciences. 813:156-165
Publikováno v:
Annals of the New York Academy of Sciences. 786:379-390
The present study clearly demonstrated that l-deprenyl confers a substantial protective effect against MPP+ in the substantia nigra zona compacta in vivo. 32.39. The protection provided by l-deprenyl may not depend on its inhibition of type B monoami
Publikováno v:
Annals of the New York Academy of Sciences. 777:356-361
Cortical neurodegeneration in Alzheimer's disease (AD) is suggested to be attributable not only to beta-protein but also to glutamate. Although degeneration of cholinergic projection to the cerebral cortex is recognized to be one of the most prominen