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Autor:
G. Vankin, E. Shevtzova, Gregory F. Oxenkrug, A. Afanasiev, S. Bachurin, T. Serkova, N. Lermontova, B. Beznosko, T. Mukhina
Publikováno v:
Annals of the New York Academy of Sciences. 890:155-166
After a single injection of cholinergic neurotoxin ethylcholine aziridinium (AF64A, 3 nmol intracerebroventricularly (i.c.v.)), rats failed to perform the tasks in the active avoidance (learning and retention paradigms) and water maze tests. N-Acetyl
Autor:
James E. Zadina, Gordon A. Barr
Publikováno v:
Annals of the New York Academy of Sciences. 897:145-153
Endomorphin-1 and endomorphin-2 are recently described peptides with high affinity and specificity for the mu opioid receptor. They are believed to be the endogenous ligands for that receptor. We describe the maturation of the endomorphins in brain a
Autor:
Wei-Qiang Gao
Publikováno v:
Annals of the New York Academy of Sciences. 884:312-327
Degeneration of hair cells (HC) and/or spiral ganglion neurons (SGN) is a major cause of hearing loss. Postnatal rat cochlear explant cultures are used to study the toxic actions of different classes of ototoxins and to identify molecules that can pr
Publikováno v:
Annals of the New York Academy of Sciences. 881:392-409
Major depression, opioid addiction, neurodegenerative diseases, and glial tumors are associated with disturbances of imidazoline receptors (IR) in the human brain. In depression, the level of a 45-kD IR protein (putative I1-IR) is increased in the br
Autor:
Stephen M. Husbands, Robin J. Tyacke, David J. Nutt, Lisa Lione, Alan L. Hudson, R. E. Gough, Peter H. Hutson, John W. Lewis, F. Murray, M. D. Lalies, P. Knight
Publikováno v:
Annals of the New York Academy of Sciences. 881:81-91
Over several years our group has sought to synthesize and identify selective ligands for imidazoline (I) receptors, in particular the I2 binding site. As a consequence, [3H]2-(2-benzofuranyl)-2-imidazoline (2BFI) has proved extremely useful for bindi
Publikováno v:
Annals of the New York Academy of Sciences. 881:193-198
Autor:
K. Donecker, S. Menzel, Gerhard J. Molderings, M. Burian, M. Nilius, Jürgen Homann, Manfred Göthert
Publikováno v:
Annals of the New York Academy of Sciences. 881:332-343
Radioligand binding experiments carried out in cell membranes from rat and human stomach revealed the existence of non-adrenoceptor [3H]clonidine and [3H]idazoxan binding sites and of [3H]DTG (1,2-di-(2-tolyl)guanidine) binding sites. In rat stomach,
Autor:
T. Celeste Napier, Igor Mitrovic
Publikováno v:
Annals of the New York Academy of Sciences. 877:176-201
While the ventral pallidum (VP) is known to be important in relaying information between the nucleus accumbens and target structures, it has become clear that substantial information processing occurs within the VP. We evaluated the possibility that
Publikováno v:
Annals of the New York Academy of Sciences. 877:803-806
Publikováno v:
Annals of the New York Academy of Sciences. 877:707-710