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Autor:
Frederico C. Pereira, Teresa Morgadinho, Vera M. Mendes, Syed F. Ali, Elsa Marques, Carlos Fontes Ribeiro, Tice Macedo, Marta R. Rolo
Publikováno v:
Annals of the New York Academy of Sciences. 1139:212-221
The glutamate-glutamine cycle between neurons and glia is tightly related to excitatory glutamatergic and inhibitory GABAergic regulation in brain. The role of this neuron-astrocyte cross-talk on the neurotoxicity induced by amphetamines is not under
Autor:
Frank C. Barone, Giora Z. Feuerstein, Juan L. Gu, Robert R. Ruffolo, Paul G. Lysko, Tian L. Yue
Publikováno v:
Annals of the New York Academy of Sciences. 738:230-242
The antioxidant activities of carvedilol have been demonstrated in a wide variety of test systems, including (i) physicochemical (EPR studies), (ii) biochemical (measurement of lipid peroxidation and endogenous antioxidant depletion), (iii) cellular,
Autor:
Antonio Paparelli, Paola Lenzi, Paola Soldani, Francesco Fornai, G Mauceli, Carla I. Busceti, Antonio Pellegrini
Publikováno v:
Annals of the New York Academy of Sciences. 1074:191-197
alpha-Synuclein is a presynaptic protein involved in various degenerative disorders now defined as synucleinopathies. These include neurological diseases that share a few pathological features consisting of aggregates of both normal and altered alpha
Autor:
Alessia Natoli, Walter Adriani, Elsa Traina, Emma Di Consiglio, Emanuela Testai, Damiana Leo, Giovanna De Angelis, Giovanni Laviola, Carla Perrone-Capano, Maria Guarino
Publikováno v:
Annals of the New York Academy of Sciences. 1074:52-73
Exposure to methylphenidate (MPH) during adolescence is the elective therapy for attention deficit/hyperactivity disorder (ADHD) children, but raises major concerns for public health, due to possibly persistent neurobehavioral changes. Rats (30- to 4
Publikováno v:
Annals of the New York Academy of Sciences. 962:60-72
To investigate whether nitric oxide (•NO) is neurotoxic or neuroprotective in the brain, we compared the in vivo role of S-nitroso-N-acetylpenicillamine (SNAP) with that of sodium nitroprusside (SNP) on ferrous citrate-induced oxidative stress and
Autor:
James E. Zadina, Gordon A. Barr
Publikováno v:
Annals of the New York Academy of Sciences. 897:145-153
Endomorphin-1 and endomorphin-2 are recently described peptides with high affinity and specificity for the mu opioid receptor. They are believed to be the endogenous ligands for that receptor. We describe the maturation of the endomorphins in brain a
Publikováno v:
Annals of the New York Academy of Sciences. 893:126-137
Previous studies from our laboratory demonstrated that chronic stress produces molecular, morphological, and ultrastructural changes in the rat hippocampus that are accompanied by cognitive deficits. Glucocorticoid impairment of glucose utilization i
Publikováno v:
Annals of the New York Academy of Sciences. 825:1-10
As illustrated in Figure 1, a disturbance of the intracellular Ca2+ homeostasis is thought to be a common pathogenic factor for the generation of secondary nerve cell damage that develops after brain trauma or stroke or during the course of neurodege
Autor:
Mao-Tsun Lin
Publikováno v:
Annals of the New York Academy of Sciences. 813:572-580
Experiments were carried out to ascertain whether the levels of brain monoamines and cytokines are involved in the heatstroke-induced cerebral ischemia and neuronal damage. Heatstroke was induced by exposing anesthetized rats to a high ambient temper
Autor:
Christine Peterson
Publikováno v:
Annals of the New York Academy of Sciences. 663:279-293
Alterations in calcium transport appear to be functionally significant. Treatment with drugs that promote calcium uptake partially reverse some of the age-related deficits in calcium-dependent processes. Thus, the relevance of decreased calcium coupl