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Publikováno v:
Annals of the New York Academy of Sciences. 1148:367-376
Although stress is tightly connected with elevated levels of catecholamines, stress effects on target structures of catecholamine action--adrenoceptors (ARs)--has not been deeply studied yet. Similarly, very little is known about changes of muscarini
Publikováno v:
Annals of the New York Academy of Sciences. 1139:112-117
Neurotensin (NT) is a tridecapeptide associated with extrapyramidal and limbic pathways and is thought to inhibit dopamine (DA) functions in nigrostriatal, mesocortical, and mesolimbic systems. Because of these effects, NT has been referred to as an
Publikováno v:
Annals of the New York Academy of Sciences. 499:156-166
Experiments using the binding of various ligands for monoamines to rat brain membranes and synaptosomal preparations for studying monoamine uptake and release have shown that d-fenfluramine is more potent than the l isomer in inhibiting 5-HT uptake,
Autor:
Kenzo Kawai, Hiroyuki Nishikawa, Fumiko Sekiguchi, Satoko Kubo, Ichiko Doe, Atsufumi Kawabata, Tsuyoshi Ishiki, Hirofumi Matsui
Publikováno v:
Annals of the New York Academy of Sciences. 1091:445-459
Proteinase-activated receptor-1 (PAR1), a G protein-coupled receptor (GPCR) for thrombin, can be activated not only by PAR1-activating peptides (PAR1APs) based on the N-terminal cryptic tethered ligand sequence but also by an N-palmitoylated (Pal) pe
Publikováno v:
Annals of the New York Academy of Sciences. 1088:230-237
Fatigue is evoked not only by peripheral factors, such as muscle fatigue, but also by the central nervous system (CNS). For example, it is generally known that the feeling of fatigue is greatly influenced by psychological aspects, such as motivation.
Autor:
Abdu Adem, Irwin S. Chandranath, Sheela Benedict, Mohamed A. Fahim, Enyioma N. Obineche, Ernest Adeghate
Publikováno v:
Annals of the New York Academy of Sciences. 1084:223-234
Diabetes mellitus (DM) shows a markedly increased incidence of cardiovascular pathology that leads to hypertension, endothelial macro- and microangiopathy, diabetic nephropathy, and myocardial infarction. Atrial natriuretic peptide (ANP), is a 28 ami
Autor:
Syed F. Ali, Arne Boman, Lars Wiklund, Torbjörn Lundstedt, Hari Shanker Sharma, Elisabeth Seifert, Per Lek
Publikováno v:
Annals of the New York Academy of Sciences. 1074:482-496
The possibility that a serotonin 5-HT2c receptor-modulating compound, AP-267, will influence spontaneous morphine withdrawal symptoms and the alterations in the brain fluid microenvironment was examined in a rat model. Daily administration of morphin
Spinal Cord Neuroplasticity following Repeated Opioid Exposure and Its Relation to Pathological Pain
Autor:
David J. Mayer, Jianren Mao
Publikováno v:
Annals of the New York Academy of Sciences. 933:175-184
Convincing evidence has accumulated that indicates neuroplastic changes within the spinal cord in response to repeated exposure to opioids. Such neuroplastic changes occur at both cellular and intracellular levels. It has been generally acknowledged
Autor:
Pierre-A.H. Noailles, Jesus A. Angulo
Publikováno v:
Annals of the New York Academy of Sciences. 965:267-273
The psychostimulant cocaine is an indirect agonist that increases synaptic dopamine (DA) by binding with high affinity to the DA transporter (DAT) and blocking the active transport of synaptic DA back into the terminal. The resulting increase in extr
Autor:
Martin R. Farlow, Nigel H. Greig, Donald K. Ingram, Tadanobu Utsuki, Debomoy K. Lahiri, M. Shoaib, Demao Chen
Publikováno v:
Annals of the New York Academy of Sciences. 965:364-372
Alzheimer's disease (AD) is characterized by cerebrovascular deposition of the amyloid beta-peptide (A beta), which is derived from a larger beta-amyloid precursor protein (beta APP). Altered metabolism of beta APP, resulting in increased A beta prod