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Publikováno v:
Annals of the American Thoracic Society
Respiratory tissues are bombarded by billions of particles daily. If allowed to accumulate, these particles can cause injury, inflammation, or infection, and thus may significantly disrupt airflow and gas exchange. Mucociliary defense, a primary mech
Publikováno v:
Thornton, D, Sharpe, C & Ridley, C 2018, ' Intracellular processing of human secreted polymeric airway mucins ', Annals of the American Thoracic Society, vol. 15, no. S3 . https://doi.org/10.1513/AnnalsATS.201802-143AW
Mucociliary clearance is a crucial component of innate defense of the lung. In respiratory diseases, such as asthma, chronic obstructive pulmonary disease, and cystic fibrosis, mucus with abnormal properties contributes to obstruction of the airways.
Publikováno v:
S382
S374
S374
The mitochondrion is the main site of energy production and a hub of key signaling pathways. It is also central in stress-adaptive response due to its dynamic morphology and ability to interact with other organelles. In response to stress, mitochondr
Autor:
Freddy Romero, Ross Summer
Publikováno v:
Annals of the American Thoracic Society. 14:S410-S413
Alveolar epithelial type II (AEII) cells are “professional” secretory cells that synthesize and secrete massive quantities of proteins to produce pulmonary surfactant and maintain airway immune defenses. To facilitate this high level of protein s
Autor:
Lior Atia, Stephen J. DeCamp, Jennifer A. Mitchel, Jeffrey J. Fredberg, Yasha Sharma, Christalyn Sims Rhodes
Publikováno v:
Annals of the American Thoracic Society. 15:S35-S37
The formation of an integrated tissue from individual cells depends on the properties of the individual cells as well as the interaction of many cells acting as a collective. Three fundamental physiological processes govern the collective scaling fro
Autor:
Stefan W. Ryter, Kenji Mizumura, Mary E. Choi, Shu Hashimoto, Kiichi Nakahira, Augustine M.K. Choi, Suzanne M. Cloonan
Publikováno v:
Annals of the American Thoracic Society. 13:S40-S47
Autophagy is a highly conserved process by which cells can recycle organelles and proteins by degrading them in the lysosomes. Although autophagy is considered a dynamic system responsible for cellular renovation and homeostasis under physiological c
Autor:
Daniel J. Tschumperlin
Publikováno v:
Annals of the American Thoracic Society. 12:S24-S29
The extracellular matrix (ECM) of the lung serves as both a scaffold for resident cells and a mechanical support for respiratory function. The ECM is deposited during development and undergoes continuous turnover and maintenance during organ growth a
Autor:
Eric S. White
Publikováno v:
Annals of the American Thoracic Society. 12:S30-S33
Extracellular matrix (ECM) is a tissue-specific macromolecular structure that provides physical support to tissues and is essential for normal organ function. In the lung, ECM plays an active role in shaping cell behavior both in health and disease b
Autor:
Darrell N. Kotton, Finn Hawkins
Publikováno v:
Annals of the American Thoracic Society. 12:S50-S53
The discovery of embryonic and induced pluripotent stem cells (ESCs and iPSCs) has ushered in an exciting new era of regenerative medicine. Human pluripotent stem cells can be "directed" in vitro toward lung epithelium by applying specific stepwise c