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Publikováno v:
Annals of Otology, Rhinology & Laryngology. 114:645-651
Objectives: This study was performed to explore the antimicrobial activity of two commercially available oxymetazoline hydrochloride preparations against the common pathogens of otitis media and to demonstrate the lack of ototoxicity of these agents
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 111:376-381
The present study was undertaken to determine whether adenosine attenuates cochlear dysfunction induced by transient ischemia. Adenosine or erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA), an adenosine deaminase inhibitor, was administered by perilymphat
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 108:554-558
The effect of an antiallergic drug on the evacuation of middle ear effusion (MEE) from the tubotympanum was investigated by means of an animal model with both otitis media with effusion (OME) and allergic rhinitis. Azelastine hydrochloride (AZ), an o
Autor:
Mitsuya Suzuki, Kimitaka Kaga
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 106:971-975
Our objective was to compare changes in the basement membrane anionic sites (BMAs) in the ampulla, macula, and stria vascularis following the infusion of cisplatin (CDDP). After CDDP was administered to anesthetized Hartley guinea pigs, the bony laby
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 106:599-603
The mechanism of hearing loss due to the administration of intravenous erythromycin was investigated in the albino guinea pig, and it was found for the first time that this drug causes cochlear dysfunction. The endocochlear potential (EP) and the coc
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 105:54-57
Cephalosporins are nonototoxic antibiotics that provide excellent coverage for almost all bacteria that can cause suppurative labyrinthitis. In this study we performed comparative perilymph permeability determinations of the three cephalosporins that
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 102:537-542
Time course studies of electrocochleography and the auditory brain stem response were performed in guinea pigs that were passively sensitized by sera containing antidinitrophenyl reaginic antibody and specifically challenged by dinitrophenyl—bovine
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 101:78-81
Guinea pigs were passively sensitized by sera containing antidinitrophenyl reaginic antibody and specifically challenged by dinitrophenyl-bovine serum albumin injected through the stylomastoid foramen. Nystagmus, head deviation, negative summating po
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 103:983-985
Clinical and experimental data indicate that aminoglycoside ototoxicity occurs more frequently in individuals previously exposed to ototoxic drugs. This study investigated the auditory effect of repetitive administration of kanamycin on newborn guine
Publikováno v:
Annals of Otology, Rhinology & Laryngology. 83:111-118
The ototoxicity of ethacrynic acid and kanamycin in combination has been investigated during acute and chronic conditions of exposure. The effect of the combination of 10 mg/kg of ethacrynic acid and 100 mg/kg of kanamycin during both exposure condit