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Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Universidad de Barcelona
Background: We conducted a systematic literature review and meta-analysis of observational studies investigating adherence to the 2007 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) lifestyle recommendations for cancer
Autor:
Ute Ohnmacht, C. Le Tourneau, Gerard J. Oakley, Christophe Massard, Analia Azaro, Jordi Rodon, Debashis Sarker, Karim A. Benhadji, Bharvin K. R. Patel, Ulrik Lassen, Claire Smith, Eunice Yuen, Jean-Charles Soria
Publikováno v:
Massard, C, Azaro, A, Soria, J C, Lassen, U, Le Tourneau, C, Sarker, D, Smith, C, Ohnmacht, U, Oakley, G, Patel, B K R, Yuen, E S M, Benhadji, K A & Rodon, J 2018, ' First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer ', Annals of Oncology, vol. 29, no. 9, pp. 1911-1917 . https://doi.org/10.1093/annonc/mdy244
Background Deregulated Notch signaling due to mutation or overexpression of ligands and/or receptors is implicated in various human malignancies. γ-Secretase inhibitors inhibit Notch signaling by preventing cleavage of transmembrane domain of Notch
Autor:
J. B. Fan, M. Bibikova, Haojie Huang, R. Shen, Hyunseon C. Kang, B. Barnes, Filip Janku, S. L. Moulder, E. S. Kopetz, Rodabe N. Amaria, Charles Lu, Toshinori Hinoue, Peter W. Laird, Hui Shen, Vivek Subbiah, K. Gutekunst, G. Granger, Li Liu, Sarina Anne Piha-Paul, David S. Hong, A. F. Jassowicz, Siquing Fu, Apostolia-Maria Tsimberidou, Neeraj Salathia, Raakhee Vijayaraghavan, Cathy Eng, Ruoyu Zhang, Aung Naing, K. M. Kruglyak, Funda Meric-Bernstam, J. M. Toung
Publikováno v:
Annals of Oncology. 29:1445-1453
Targeted methylation sequencing of plasma cell-free DNA (cfDNA) has a potential to expand liquid biopsies to patients with tumors without detectable oncogenic alterations, which can be potentially useful in early diagnosis.We developed a comprehensiv
Autor:
Susana Inogés, Ignacio Gil-Bazo, L. Resano, Pedro Berraondo, A.M. Salazar, Benigno Barbés, Guiomar Perez, C. De Andrea, Salvador Martín-Algarra, Mariano Ponz-Sarvise, Miguel F. Sanmamed, Ignacio Melero, A. Lopez-Diaz de Cerio, Carmen Oñate, Carlos Alfaro, Maria E. Rodriguez-Ruiz, Amparo Benito, Alfonso Gurpide, Jose Luis Perez-Gracia, Inmaculada Rodriguez
Publikováno v:
Annals of Oncology. 29:1312-1319
Background Combination immunotherapy has the potential to achieve additive or synergistic effects. Combined local injections of dsRNA analogues (mimicking viral RNA) and repeated vaccinations with tumor-lysate loaded dendritic cells shows efficacy ag
Autor:
Prudence R. Carr, Hermann Brenner, S. Bienert, Michael Hoffmeister, Elizabeth Alwers, Matthias Kloor, Janick Weberpals
Publikováno v:
Annals of Oncology. 29:825-834
Introduction The association of lifestyle factors with molecular pathological subtypes of colorectal cancer (CRC), such as microsatellite instability (MSI), could provide further knowledge about the colorectal carcinogenic process. The aim of this re
Autor:
C. La Vecchia, Paola Bertuccio, Paolo Boffetta, Fabio Levi, Matteo Malvezzi, Eva Negri, Greta Carioli
Publikováno v:
Annals of Oncology. 29:1016-1022
Background We projected cancer mortality statistics for 2018 for the European Union (EU) and its six more populous countries, using the most recent available data. We focused on colorectal cancer. Materials and methods We obtained cancer death certif
Autor:
William P. Harris, D. Ciznadija, Justin Stebbing, Andrew Gaya, Ido Sloma, Harvey I. Pass, K. Paz, Ronnie Morris, Angela M. Davies, Rajani Ravi, Manuel Hidalgo, Atul Bedi, David Sidransky, Ido Ben-Zvi, Leonard H. Wexler, William P. McGuire, Carlos Rodriguez-Galindo, S. Zacharoulis, Amos Katz, Nir Peled, Robert G. Maki, Mohammad O. Hoque, David Vasquez-Dunddel, Evgeny Izumchenko
Publikováno v:
Annals of Oncology. 28:2595-2605
Background: While patient-derived xenografts (PDXs) offer a powerful modality for translational cancer research, a precise evaluation of how accurately patient responses correlate with matching PDXs in a large, heterogeneous population is needed for
Prognostic role of tumor PIK3CA mutation in colorectal cancer: a systematic review and meta-analysis
Publikováno v:
Annals of Oncology. 27:1836-1848
Background Somatic mutations in the phosphatidylinositol-4,5-bisphosphate 3-kinase/AKT pathway play a vital role in carcinogenesis. Approximately 15%–20% of colorectal cancers (CRCs) harbor activating mutations in PIK3CA, making it one of the most
Autor:
L.F. von Weikersthal, U. Graeven, Thomas Kirchner, Clemens Giessen-Jung, W. Schmiegel, Rainer Porschen, Dominik Paul Modest, S. Hegewisch-Becker, Andrea Tannapfel, Anke Reinacher-Schick, H.-J. Schmoll, Arndt Stahler, Dirk Arnold, Sebastian Stintzing, Ingrid Ricard, Andreas Jung, Volker Heinemann
Publikováno v:
Annals of Oncology
In this pooled analysis of metastatic colorectal cancer patients, mutations in KRAS, and BRAF were associated with inferior progression-free and overall survival compared with patients with non-mutated tumors. KRAS exon 2 mutation variants were assoc
Autor:
Daisuke Takahari, Masashi Ueno, Takeshi Suzuki, Yosuke Fukunaga, R. Kozuki, K. Chin, Tsuyoshi Konishi, Kensei Yamaguchi, S. Nagayama, T. Wakatuki, Eiji Shinozaki, Mitsukuni Suenaga, Toshiya Nagasaki, Michinori Ogura, Hiroki Osumi, I. Nakayama
Publikováno v:
Annals of Oncology. 30:ix38-ix39
Background Carcinoembryonic antigen (CEA) is the most widespread tumour marker of colorectal cancer, however, it is not helpful to judge for recurrence of the disease because of low sensitivity and specificity. It is recommended for patients who were