Zobrazeno 1 - 10
of 469
pro vyhledávání: ''
Autor:
G. Speranza, Helge Bischoff, Enriqueta Felip, Steven Francis Powell, Shirish M. Gadgeel, Maximilian Hochmair, F. De Angelis, Manuel Domine, Emilio Esteban, Edward B. Garon, Delvys Rodriguez-Abreu, Takayasu Kurata, J. Yang, N. Peled, Rina Hui, Martin Reck, S. Cheng, M.C. Pietanza, Fabricio Souza, M.C. Garassino, Michael Boyer
Publikováno v:
Annals of Oncology. 32:881-895
Background In the phase III KEYNOTE-189 study (NCT02578680), pembrolizumab plus pemetrexed and platinum-based chemotherapy (pemetrexed–platinum) significantly improved overall survival (OS) and progression-free survival (PFS) in patients with previ
Autor:
Sonal Shad, William Fraser Symmans, Debu Tripathy, Lamorna Brown-Swigart, LJ Esserman, Jane Perlmutter, V. Valero, Rebekah Gould, Gregor Krings, Judy C. Boughey, Jodi M. Carter, M. van der Noordaa, Gillian L. Hirst, L.J. van 't Veer, Christina Yau, Douglas Yee, Lajos Pusztai, Tufia C. Haddad, Kathy S. Albain, Molly Klein, Lili Du, MC Liu, Rita Nanda, Claudine Isaacs, Richard Schwab, Amy Jo Chien, Donald A. Berry, Rachel M. Layman, AM DeMichele, Isabelle Bedrosian, Sara J. Venters, Nola M. Hylton
Publikováno v:
Annals of Oncology. 32:642-651
BACKGROUND We proposed that a test for sensitivity to the adjuvant endocrine therapy component of treatment for patients with stage II-III breast cancer (SET2,3) should measure transcription related to estrogen and progesterone receptors (SETER/PR in
Autor:
N. Pardo Aranda, Clarisse Audigier-Valette, Juergen Wolf, David Vicente, Scott J. Antonia, Dimple Pandya, Kazuhiko Nakagawa, David R. Spigel, Solange Peters, Alexander Luft, M. Shi, Ying Cheng, O. Juan-Vidal, Scott N. Gettinger, Martin Reck, J. Fairchild, Parul Doshi, Tudor-Eliade Ciuleanu, Leora Horn, Han Chang, Christine Baudelet, H. Zhang
Publikováno v:
ANNALS OF ONCOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Patients with relapsed small-cell lung cancer (SCLC) have few treatment options and dismal survival. Phase I/II data show activity of nivolumab in previously treated SCLC.CheckMate 331 is a randomized, open-label, phase III trial of nivolumab versus
Autor:
William A. Wegener, David M. Goldenberg, RL Moroose, Joyce O'Shaughnessy, Dejan Juric, Aditya Bardia, Sara M. Tolaney, Jennifer R. Diamond, Vandana G. Abramson, Ingrid A. Mayer, Pius Maliakal, Linda T. Vahdat, T. Goswami, Kevin Kalinsky, Robert M. Sharkey, Q. Hong
Publikováno v:
Ann Oncol
Background Trophoblast cell-surface antigen-2 (Trop-2) is expressed in epithelial cancers, including hormone receptor-positive (HR+) metastatic breast cancer (mBC). Sacituzumab govitecan (SG; Trodelvy®) is an antibody–drug conjugate composed of a
Autor:
M. Bahl, Demetrios Simos, Ricardo Fernandes, Jacques Raphael, Nadia Califaretti, Brian Hutton, L. Zibdawi, Carol Stober, Mark Clemons, Ranjeeta Mallick, Deanna Saunders, Andrew Robinson, Lacey D. Pitre, Mohamed F.K. Ibrahim, John Hilton, Dean Fergusson, Olexiy Aseyev, Arif Awan, Lisa Vandermeer, Gregory R. Pond, M. Mates
Publikováno v:
Annals of Oncology
Background The optimal duration of filgrastim as primary febrile neutropenia (FN) prophylaxis in early breast cancer patients is unknown, with 5, 7 or 10 days being commonly prescribed. This trial evaluates whether 5 days of filgrastim was non-inferi
Autor:
Rachel Schiff, Mothaffar F. Rimawi, Matthew P. Goetz, Jorge S. Reis-Filho, Ting Wang, Britta Weigelt, Carolina Gutierrez, CK Osborne, Aleix Prat, Suzanne A. W. Fuqua, Antonio C. Wolff, R. Mao, Jamunarani Veeraraghavan, Andres Forero, Anna C. Pavlick, Paolo Nuciforo, Ingrid A. Mayer, C. De Angelis, SG Hilsenbeck, Jenny C. Chang, Ian E. Krop, Rita Nanda, Sabrina Herrera, Alejandro Contreras
Publikováno v:
Ann Oncol
BACKGROUND: HER2-positive (+) breast cancers, defined by HER2 overexpression and/or amplification, are often addicted to HER2 to maintain their malignant phenotype. Yet, some HER2+ tumors do not benefit from anti-HER2 therapy. We hypothesize that HER
Autor:
Jingjing Miao, Chong Zhao, Xi Chen, Jun Chen, Melvin L.K. Chua, M. Shi, Fei Han, X. Hu, G.-P. Shen, X. Shao, Jia Li, N. Zhang, Hai-Qiang Mai, Conghua Xie, Guoqing Hu, Lin Wang, Shiwei Wu
Publikováno v:
Annals of Oncology. 30:637-643
We conducted a single-arm phase II trial to evaluate the efficacy and adverse effects (AEs) of an anti-epidermal growth factor receptor monoclonal antibody, nimotuzumab, combined with cisplatin and 5-fluorouracil (PF) as first-line treatment in recur
Publikováno v:
Annals of Oncology
Prediction of benefit from adjuvant chemotherapy following resection of early breast cancer and, as a result, proper selection of candidates remains an elusive goal since the relative magnitude of benefit is the same regardless of the presence of cli
Autor:
G.L. De Salvo, G. Moretti, Patricia Galván, Maria Vittoria Dieci, Giancarlo Bisagni, R. Vicini, Gaia Griguolo, Giulia Bianchi, Aleix Prat, Massimo Ambroggi, Tomás Pascual, Laia Paré, Loredana Urso, Antonio Frassoldati, Carlo Alberto Giorgi, Pierfranco Conte, Enrico Orvieto, Valentina Guarneri
Publikováno v:
Annals of Oncology
Background In human epidermal growth factor receptor 2 (HER2+) breast cancers, neoadjuvant trials of chemotherapy plus anti-HER2 treatment consistently showed lower pathologic complete response (pCR) rates in hormone receptor (HR) positive versus neg
Autor:
Conte, P., Frassoldati, A., Bisagni, G., Brandes, A. A., Donadio, M., Garrone, O., Piacentini, F., Cavanna, L., Giotta, F., Aieta, M., Gebbia, V., Molino, A., Musolino, A., Ferro, A., Maltoni, R., Danese, S., Zamagni, C., Rimanti, A., Cagossi, K., Russo, A., Pronzato, P., Giovanardi, F., Moretti, G., Lombardo, L., Schirone, A., Beano, A., Amaducci, L., Bajardi, E. A., Vicini, R., Balduzzi, S., D'Amico, R., Guarneri, Falci C, V., Giarratano, T, Mcmahon, L, De Salvo GL, Dieci, Mv, Maiorana, A, Ficarra, G, Caggia, F, Grisolia, D, Bartolini, S, Lorusso, V, Ardito, R, Tartarone, A, Vanella, P, Taverniti, C, Porpiglia, M, Spanu, Pg, Biglia, N, Andreis, D, Piancastelli, A, Fedeli, A, Parra, Hs, Gambaro, Ar, Romito, S, Malossi, A, Gori, S, Miglietta, L, Del Mastro, L, Amoroso, D, Mansutti, M, Generali, D, Prati, G, Bertolini, A, Berardi, R, Zanni, A, Cottafavi, L, Bologna, A, Naso, G, Pancotti, A, Farci, D, Zoboli, A, Silva, R, Laudadio, L, Bordonaro, R, Marenco, D, Dongiovanni, V, Baldini, E, Saggia, C, Gorzegno, G, Cariello, A, Biganzoli, L, Rampello, E.
Publikováno v:
Annals of Oncology. 29:2328-2333
Background: Chemotherapy plus 1-year trastuzumab is the standard adjuvant treatment of HER2-positive breast cancer. The efficacy of less extended trastuzumab exposure is under investigation. The short-HER study was aimed to assess the non-inferiority