Zobrazeno 1 - 10
of 16
pro vyhledávání: '"35"'
Publikováno v:
Annals of Neurology
Objective: Because cholinergic deficits are prominent in dementia with Lewy bodies (DLB), we investigated the effects of a cholinesterase inhibitor, donepezil, in such patients in a randomized, double-bilnd- placebo-controlled exploratory phase 2 tri
Autor:
Donald B. Calne, A. Jon Stoessl, Lisa Kuramoto, Raúl de la Fuente-Fernández, Chong S. Lee, Siobhan McCormick, Jacquelyn J. Cragg, Wing Lok Au, Edwin Mak, Vesna Sossi, Jess McKenzie, Michael Schulzer, Thomas J. Ruth, Nandhagopal Ramachandiran
Publikováno v:
Annals of Neurology. 69:803-810
Objective: To investigate in vivo the impact of age on nigrostriatal dopamine dysfunction in Parkinson's disease (PD). Methods: PD patients (n = 78) and healthy control subjects (n = 35) underwent longitudinal positron emission tomography assessments
Autor:
Jordan Popper, Kamal Masaki, Lenore J. Launer, Caroline M. Tanner, Lon R. White, Robert D. Abbott, G. Webster Ross, Helen Petrovitch
Publikováno v:
Annals of Neurology. 63:167-173
Objective Although olfactory dysfunction is commonly associated with Parkinson's disease (PD), it is not known whether such dysfunction can predate the onset of clinical PD in a community-based population. This study examines the association of olfac
Publikováno v:
Annals of Neurology. 61:324-331
Objective Different pathophysiological mechanisms related to the balance of cortical excitatory and inhibitory influences may underlie focal and generalized epilepsies. We used transcranial magnetic stimulation to search for interictal excitability d
Publikováno v:
Annals of Neurology. 41:58-64
Clinical scales, based on the major signs of Parkinson's disease (PD), are commonly used to assess the effect of symptomatic treatment of PD. With the appearance of therapy aiming to rescue or protect the nigrostriatal neurons in PD, it becomes essen
Autor:
Martijn L.T.M. Müller, Kirk A. Frey, Nicolaas I. Bohnen, Ronald D. Chervin, Vikas Kotagal, Robert A. Koeppe, Roger L. Albin
Publikováno v:
Annals of neurology. 71(4)
Objective: Rapid eye movement sleep behavior disorder (RBD) is common in Parkinson disease (PD), but its relationship to the varied neurotransmitter deficits of PD and prognostic significance remain incompletely understood. RBD and cholinergic system
Autor:
Phyllis Antis, Howard Crystal, Ellen Grober, Martin J. Sliwinski, Richard B. Lipton, Harriet Marks‐Nelson, Dennis W. Dickson
Publikováno v:
Annals of Neurology. 34:566-573
We investigated the associations of pathological markers of Alzheimer's disease (AD) and diffuse Lewy body disease as well as possible markers of vascular dementia with cognitive function in a sample of 20 nondemented and 35 demented subjects (median
Autor:
Clifford R. Jack, F. W. Sharbrough, P. C. O'Brien, Gregory D. Cascino, W. R. Marsh, K. A. Hirschorn
Publikováno v:
Annals of Neurology. 31:138-146
We developed a magnetic resonance imaging (MRI)–based technique for measuring the volume of the hippocampal formation. In this study, the relationship between volumes of the hippocampal formation and outcome (i.e., postoperative seizure control) af
Publikováno v:
Annals of neurology. 42(3)
We examined the response to 2-hour levodopa infusions in 18 Parkinson's disease subjects before starting long-term levodopa treatment and after 6 and 12 months of treatment using tapping speed as an index of bradykinesia. The long-duration response (
Autor:
Vijay M. Thadani, Dennis D. Spencer, Richard H. Mattson, Susan S. Spencer, Peter D. Williamson, Terrance M. Darcey, Jacqueline A. French
Publikováno v:
Annals of neurology. 34(6)
In order to more precisely define a syndrome of medial temporal lobe epilepsy, histories and physical findings were evaluated in 67 patients studied with intracranial electrodes who had medial temporal seizure onset and became seizure free following