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Publikováno v:
Angiology. 72:411-425
Nitric oxide (NO) is a powerful mediator with biological activities such as vasodilation and prevention of vascular smooth muscle cell proliferation as well as functional regulation of cardiac cells. Thus, impaired production or reduced bioavailabili
Publikováno v:
Angiology. 70:896-907
Factor Xa (FXa) is the key serine protease of the coagulation cascade as it is the point of convergence of the intrinsic and extrinsic pathways, leading to the formation of thrombin. Factor Xa is an established target of anticoagulation therapy, due
Autor:
Sofia Giannitsi, Athanasios J. Manolis, Manolis S. Kallistratos, Pavlos Tsinivizov, Leonidas E. Poulimenos
Publikováno v:
Angiology. 70:291-298
Trimetazidine (TMZ) is a metabolic agent with significant anti-ischemic properties. By inhibiting the terminal enzyme in the β-oxidation pathway, it shifts the energy substrate metabolism, enhancing glucose metabolism. Thus, it maintains the require
Autor:
Nikolaos Tsilimingas, Filippos Triposkiadis, Antigoni Lazou, Georgios I Tagarakis, Christos Voucharas
Publikováno v:
Angiology. 63:416-419
We suggest a new, easily applicable way of myocardial hypertrophy induction in rats. Forty randomized age-matched male Wistar rats were divided into 2 groups of 20 each: a control group and an orally administered fludrocortisone/salt group. Myocardia
Autor:
Despina Perrea, Dimitri P. Mikhailidis, George Agrogiannis, Ioannis S. Vlachos, Kosmas I. Paraskevas, Dimitrios G. Iliopoulos, Dimitrios Tzivras, Alkistis Pantopoulou, Gabriel Karatzas
Publikováno v:
Angiology. 62:144-154
Background and Aim: The treatment-of-choice for the optimal management of the dyslipidemia of the metabolic syndrome (MetS) is not clearly defined. We compared the efficacy of 4 drug regimes for the management of this dyslipidemia in a mouse model. M
Publikováno v:
Angiology. 61:437-442
We assessed the effect of novel immunotherapeutic heat-killed bacterial (Actinomycetales) preparations on the development of myointimal hyperplasia (MIH) in a rat carotid balloon trauma model and the effect on the immune response by measuring the exp
Can Statins Suppress the Development of Abdominal Aortic Aneurysms? A Review of the Current Evidence
Publikováno v:
Angiology. 61:137-144
Statins possess several pleiotropic effects and have been shown in vitro and in vivo to inhibit the expression of inflammatory mediators and downregulate molecules involved in extracellular matrix (ECM) degradation. Recent observational studies in hu
Autor:
Ana C. Palei, Geisa M. Fortuna, Jose E. Tanus-Santos, Rafael Alves Gomes Zaneti, Raquel F. Gerlach
Publikováno v:
Angiology. 56:611-617
The authors examined whether acute pulmonary embolism (APE) increases lung matrix metalloproteinase (MMP)-2 and MMP-9 activities and whether inhibition of MMPs with doxycycline attenuates the hemodynamic changes associated with APE. Anesthetized male
Autor:
Koji Ohmori, Masakazu Kohno, Stephane Lafitte, Barry Peters, G. Monet Strachan, Hisashi Masugata, Katsufumi Mizushige
Publikováno v:
Angiology. 54:443-448
The authors examined the ability of real-time myocardial contrast echocardiography (MCE) to assess adenosine-induced coronary steal in the setting of coronary artery occlusion. The left anterior descending (LAD) coronary artery was occluded in 8 open
Autor:
Dimitri P. Mikhailidis, Moses Elisaf
Publikováno v:
Angiology. 53:493-502
Renal disease is often associated with an increased risk of vascular events. Moreover, an accelerated form of atherosclerosis commonly occurs in these patients. The reasons for these associations are not clearly defined but include the widespread pre