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Publikováno v:
Anesthesiology. 134:617-625
Background The median effective dose of ropivacaine required for producing an effective costoclavicular block has not yet been determined. The authors conducted this dose-finding study with the objective of determining the median effective dose of 0.
Autor:
Reine Ibala, Shubham Chamadia, Oluwaseun Akeju, Jennifer Mekonnen, Jason Z. Qu, Eunice Hahm, Juan C Pedemonte, Joseph J. Locascio, Jacob Gitlin, Katia M Colon, Breanna R Ethridge
Publikováno v:
Anesthesiology. 133:1021-1028
Background Ketamine is a dissociative anesthetic with analgesic properties. Ketamine’s analgesic properties have been suggested to result from its dissociative properties. To the authors’ knowledge, this postulate is unsubstantiated. The authors
Publikováno v:
Anesthesiology. 133:439-457
The recent demonstration of the significant reduction in mortality in patients with septic shock treated with adjunctive glucocorticoids combined with fludrocortisone and the effectiveness of angiotensin II in treating vasodilatory shock have renewed
Autor:
Armando Teixeira-Pinto, Isaura Tavares, Ana Costa, Marília Sousa, Steven P. Wilson, Isabel Martins, Carlos Reguenga
Publikováno v:
Anesthesiology. 133:628-644
Background Increased descending pain facilitation accounts for opioid-induced hyperalgesia, but the underlying mechanisms remain elusive. Given the role of µ-opioid receptors in opioid-induced hyperalgesia in animals, the authors hypothesized that t
Autor:
Jaime B. Hyman, S.S. Fenske, Stephanie V. Blank, L. Rosen, Sylvie B. Polsky, Hung-Mo Lin, Peter J. Taub, Beatriz Cole, Chang Park, Charles Ascher-Walsh, Matthew Hartnett, Rachel L. Barr Grzesh, Vijay Palvia, Samuel DeMaria
Publikováno v:
Anesthesiology. 132:1419-1428
BackgroundPostdischarge nausea and vomiting after ambulatory surgery is a common problem that is not adequately addressed in current practice. This prospective, randomized, double-blind, parallel-group, placebo-controlled study was designed to test t
Autor:
Paul L. Feldman
Publikováno v:
Anesthesiology. 132:1229-1234
Design, Synthesis, and Pharmacological Evaluation of Ultrashort- to Long-acting Opioid Analgetics. By Feldman PL, James MK, Brackeen MF, Bilotta JM, Schuster SV, Lahey AP, Lutz MW, Johnson MR, Leighton HJ. J Med Chem 1991; 34:2202-8. Copyright 1991 A
Autor:
Steven Mcguigan, Will Woods, David T. J. Liley, Suresh D. Muthukumaraswamy, Levin Kuhlmann, Andria Pelentritou, John R. Cormack
Publikováno v:
Anesthesiology. 132:1017-1033
Background Investigations of the electrophysiology of gaseous anesthetics xenon and nitrous oxide are limited revealing inconsistent frequency-dependent alterations in spectral power and functional connectivity. Here, the authors describe the effects
Autor:
Froukje H. Knotnerus, Ernesto R R Muskiet, Martine Oostra, Jan Van Bocxlaer, Michel Struys, Maud A S Weerink, Koen Reyntjens, Pieter Colin, Clemens R M Barends
Publikováno v:
Anesthesiology, 131(5), 1004-1017. LIPPINCOTT WILLIAMS & WILKINS
WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Patients sedated with standard clinical doses of dexmedetomidine can be readily arousedDexmedetomidine doses producing mild to deep sedation lack significant analgesic effectRemifentanil is an opioid analgesic w
Autor:
Jennifer H. Walsh, Malin Jonsson Fagerlund, Mika Scheinin, David R. Hillman, Åse Lodenius, Kathleen J. Maddison, Brad K. Lawther, Lars Eriksson, Peter R. Eastwood
Publikováno v:
Anesthesiology. 131:962-973
Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Dexmedetomidine is a sedative promoted as having minimal impact on ventilatory drive or upper airway muscle activity. However, a trial rece
Autor:
Necib Akman, Till Braunschweig, Benjamin Maron, Stefan Heitmeier, Herbert Schöchl, Eva Herzog, Oliver Grottke, Farahnaz Rayatdoost, Rolf Rossaint
Publikováno v:
Anesthesiology. 135(4)
Background Life-threatening bleeding requires prompt reversal of the anticoagulant effects of factor Xa inhibitors. This study investigated the effectiveness of four-factor prothrombin complex concentrate in treating trauma-related hemorrhage with ri