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Publikováno v:
Anesthesiology. 128:1092-1098
Background Minimum alveolar concentration (MAC) has traditionally been used to compare the potency of volatile anesthetics. However, as it reflects the spinal mechanism of immobility rather than the cerebral mechanism of analgesia and hypnosis, it is
Autor:
Yugo Tagaito, Naohito Shimoyama, Hiroshi Nagase, Satoshi Toyama, Tsuyoshi Saitoh, Masashi Yanagisawa, Megumi Shimoyama
Publikováno v:
Anesthesiology. 128:992-1003
Background Sleepiness and decrease in attention are dose-limiting side effects of opioids. The orexin/hypocretin system plays an important role in maintaining wakefulness. This study aimed to explore the potential of a nonpeptide orexin receptor agon
Publikováno v:
Anesthesiology. 128:867-870
Autor:
Shunji Yamada, Mohammed Shaqura, Michael K. E. Schäfer, Doaa Mohamed, Antje Beyer, Xiongjuan Li, Shaaban A. Mousa
Publikováno v:
Anesthesiology. 128:796-809
Background In naive rats, corticosteroids activate neuronal membrane–bound glucocorticoid and mineralocorticoid receptors in spinal cord and periphery to modulate nociceptive behavior by nongenomic mechanisms. Here we investigated inflammation-indu
Autor:
Paul C. Fitzgerald, Wilmer F. Davila, Suman Rao, Paloma Toledo, Elizabeth M. S. Lange, Robert J. McCarthy, Cynthia A. Wong
Publikováno v:
Anesthesiology. 128:745-753
Background Programmed intermittent boluses of local anesthetic have been shown to be superior to continuous infusions for maintenance of labor analgesia. High-rate epidural boluses increase delivery pressure at the catheter orifice and may improve dr
Publikováno v:
Anesthesiology. 128:657-670
Fibrinolysis is a physiologic component of hemostasis that functions to limit clot formation. However, after trauma or surgery, excessive fibrinolysis may contribute to coagulopathy, bleeding, and inflammatory responses. Antifibrinolytic agents are i
Autor:
Glenn S. Murphy, Joseph W. Szokol, Steven Greenberg, Michael J. Avram, Jessica Benson, Mark A. Deshur, Colleen E. Maher, Torin D. Shear, Rebecca L. Newmark
Publikováno v:
Anesthesiology. 128:27-37
Background When a muscle relaxant is administered to facilitate intubation, the benefits of anticholinesterase reversal must be balanced with potential risks. The aim of this double-blinded, randomized noninferiority trial was to evaluate the effect
Autor:
Kenneth E. Nelson, James C. Eisenach, Peter H. Pan, Jessica L. Booth, Lynnette Harris, Vernon H. Ross
Publikováno v:
Anesthesiology. 127:50-57
Background The addition of opioids to epidural local anesthetic reduces local anesthetic consumption by 20% but at the expense of side effects and time spent for regulatory compliance paperwork. Epidural neostigmine also reduces local anesthetic use.
Publikováno v:
Anesthesiology. 127:173-191
Regional anesthesia has an established role in providing perioperative analgesia for shoulder surgery. However, phrenic nerve palsy is a significant complication that potentially limits the use of regional anesthesia, particularly in high-risk patien
Autor:
Hyoungkyu Kim, Duan Li, UnCheol Lee, George A. Mashour, Paul Picton, Vijay Tarnal, Amy M. McKinney, Adrian Pichurko, Phillip E. Vlisides, Ellen Janke, Tarik Bel-Bahar, Bryan S Kunkler
Publikováno v:
Anesthesiology. 127:58-69
Background Previous studies have demonstrated inconsistent neurophysiologic effects of ketamine, although discrepant findings might relate to differences in doses studied, brain regions analyzed, coadministration of other anesthetic medications, and