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Autor:
Gregory A. Chinn, Jennifer M. Sasaki Russell, Deenu Maharjan, Nicole A. Yabut, Jeffrey W. Sall
Publikováno v:
Anesthesiology
Background Cognitive deficits after perinatal anesthetic exposure are well established outcomes in animal models. This vulnerability is sex-dependent and associated with expression levels of the chloride transporters NKCC1 and KCC2. The hypothesis wa
Autor:
Tiwari, Vinod, Anderson, Michael, Yang, Fei, Tiwari, Vineeta, Pharm, M., Zheng, Qin, He, Shao-Qiu, Zhang, Tong, Shu, Bin, Chen, Xueming, Grenald, Shaness A., Stephens, Kimberly E., Chen, Zhiyong, Dong, Xinzhong, Raja, Srinivasa N., Guan, Yun
Publikováno v:
Anesthesiology. 128:1220-1236
Background Ongoing neuropathic pain is difficult to treat. The authors examined whether dermorphin [D-Arg2, Lys4] (1–4) amide, a peripherally acting µ-opioid receptor agonist, attenuates ongoing pain-associated manifestations after nerve injury in
Autor:
Yugo Tagaito, Naohito Shimoyama, Hiroshi Nagase, Satoshi Toyama, Tsuyoshi Saitoh, Masashi Yanagisawa, Megumi Shimoyama
Publikováno v:
Anesthesiology. 128:992-1003
Background Sleepiness and decrease in attention are dose-limiting side effects of opioids. The orexin/hypocretin system plays an important role in maintaining wakefulness. This study aimed to explore the potential of a nonpeptide orexin receptor agon
Publikováno v:
Anesthesiology. 126:708-715
Background Cebranopadol is a first-in-class analgesic with agonist activity at classic opioid peptide receptors and the nociceptin/orphanin FQ peptide receptor. The authors compared the antinociceptive and respiratory depressant effects of cebranopad
Autor:
Qing Liu, Michael S. Gold
Publikováno v:
Anesthesiology. 125:755-764
BackgroundPrevious evidence suggests that opioid-tolerant patients are less responsive to local anesthetics (LAs) for postoperative pain management.MethodsTo determine whether this apparent loss of LA potency is due to an intrinsic change in the peri
Publikováno v:
Anesthesiology. 128(3)
Background The α2-adrenergic sedative/anesthetic agent dexmedetomidine exerts biphasic effects on isolated arteries, causing endothelium-dependent relaxations at concentrations at or below 30 nM, followed by contractions at higher concentrations. l-
Publikováno v:
Anesthesiology. 124(3)
Background Etomidate is a highly potent anesthetic agent that is believed to produce hypnosis by enhancing γ-aminobutyric acid type A (GABAA) receptor function. The authors characterized the GABAA receptor and hypnotic potencies of etomidate analogs
Autor:
Christopher M. Peters, Douglas G. Ririe, James C. Eisenach, Timothy T. Houle, Carol A. Aschenbrenner
Publikováno v:
Anesthesiology. 120:976-986
Background: Long-lasting, sensory-specific peripheral nerve blockade would advance perioperative analgesia. Perineural injection of a combination of transient receptor potential vanilloid 1 channel agonists and lidocaine or its hydrophilic derivative
Publikováno v:
Anesthesiology. 124(5)
Background Tissue injury enhances pain sensitivity both at the site of tissue damage and in surrounding uninjured skin (secondary hyperalgesia). Secondary hyperalgesia encompasses several pain symptoms including pain to innocuous punctate stimuli or
Publikováno v:
Anesthesiology. 114:135-149
Background Postoperative pain can occur despite nerve blocks during the surgical period. Here we tested Xybrex (Orthocon, Inc., Irvington, NY), a slow-release formulation of lidocaine that blocks rat sciatic nerve for 1-2 days, for its ability to sup